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Thymosin Alpha-1Evidence & Dosage

Immunomodulation, viral infections, and cancer adjuvant.

Studies last updated

Evidence at a glance

Total studies
487
With abstract
50
Meta / Systematic / RCT
60
Highly cited
50
Publication years
1972–2026

Thymosin Alpha-1 in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Thymosin Alpha-1

Ranked by influential-citation count and publication year.

  1. Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1.

    J Immunol1982Study49 influential citations

    A sensitive and specific radioimmunoassay (RIA) has been developed to measure thymosin alpha 1 in human blood and tissue extracts. Thymosin alpha 1, originally isolated from bovine thymosin fraction 5, has an identical primary structure in…

  2. Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis.

    Cancer Res2022Study45 influential citations

    The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance of apoptotic tumor cells, also known as efferocytosis, is an immunologically silent…

  3. Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy.

    Cell reports. Medicine2024n=10E45 influential citations

    Although oncolytic adenoviruses are widely studied for their direct oncolytic activity and immunomodulatory role in cancer immunotherapy, the immunosuppressive feedback loop induced by oncolytic adenoviruses remains to be studied. Here, we…

  4. Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial.

    Hepatology1991n=12RCT44 influential citations

    Chronic hepatitis B is a severe and frequently progressive disease. We assessed the safety and efficacy of thymosin fraction 5 and thymosin-alpha 1 in a prospective, placebo-controlled trial in 12 patients with chronic hepatitis B. All…

  5. Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial.

    Intensive Care Med2022n=508RCT44 influential citations

    <h4>Purpose</h4>Infected pancreatic necrosis (IPN) is a highly morbid complication of acute necrotising pancreatitis (ANP). Since there is evidence of early-onset immunosuppression in acute pancreatitis, immune enhancement may be a…

  6. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.

    Blood2004Study35 influential citations

    Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic…

  7. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis.

    Nat Med2017n=8Study31 influential citations

    Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that compromise its chloride channel activity. The most common mutation, p.Phe508del, results in the production…

  8. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial.

    Crit Care2013n=361RCT30 influential citations

    <h4>Introduction</h4>Severe sepsis is associated with a high mortality rate despite implementation of guideline recommendations. Adjunctive treatment may be efficient and require further investigation. In light of the crucial role of…

  9. Thymosins: structure, function and therapeutic applications.

    Thymus1984Clinical Trial25 influential citations

    Using a partially purified preparation, thymosin fraction 5, we have documented that thymosin can correct many of the immunological deficiencies resulting from the lack of thymosin function in animal models and in humans. Ongoing studies…

  10. A randomized trial to evaluate the immunorestorative properties of synthetic thymosin-alpha 1 in patients with lung cancer.

    J Biol Response Mod1985n=42RCT25 influential citations

    A randomized trial was performed in 42 postradiotherapy patients with non-small cell lung cancer to determine whether the administration of synthetic thymosin-alpha 1 by either a loading dose or a twice-weekly schedule could accelerate the…

Frequently asked

Are there safety considerations for Thymosin Alpha-1?
• No significant side effects were observed with thymosin or placebo. • Bleeding was 6.3% with Tα1 vs 3.5% with placebo. • New-onset organ failure was 10.6% with Tα1 vs 15% with placebo. • Gastrointestinal fistula was 2% with Tα1 vs 2.4% with placebo.

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