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GHRP-6Evidence & Dosage

GH releaser with a strong appetite component.

Evidence at a glance

Total studies
73
With abstract
50
Meta / Systematic / RCT
0
Highly cited
31
Publication years
2000–2026

GHRP-6 in the context of Peptides

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Top studies on GHRP-6

Ranked by influential-citation count and publication year.

  1. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.

    Proceedings of the National Academy of Sciences of the United States of America2004138 influential citations

    Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of tissue extracts in a cell line…

  2. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure.

    Circulation2001104 influential citations

    <h4>Background</h4>Ghrelin is a novel growth hormone (GH)-releasing peptide that may also induce vasodilation and stimulate feeding through GH-independent mechanisms. We investigated whether ghrelin improves left ventricular (LV)…

  3. Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression.

    Endocrinology200079 influential citations

    Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), was originally purified from the rat stomach. Like the synthetic GHSs, ghrelin specifically releases GH following intravenous administration. Also…

  4. Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress.

    Biological psychiatry201268 influential citations

    <h4>Background</h4>Ghrelin plays important roles in glucose metabolism, appetite, and body weight regulation, and recent evidence suggests ghrelin prevents excessive anxiety under conditions of chronic stress.<h4>Methods</h4>We used…

  5. A 2024 Update on Growth Hormone Deficiency Syndrome in Adults: From Guidelines to Real Life.

    Journal of clinical medicine202450 influential citations

    <b>Background:</b> Adult growth hormone deficiency (GHD) has been recognized since the late 1980s. The clinical manifestations of adult GHD are often nonspecific, and diagnosis relies on GH stimulation tests, which are intricate, costly,…

  6. Ghrelin alleviates anxiety- and depression-like behaviors induced by chronic unpredictable mild stress in rodents.

    Behavioural brain research201749 influential citations

    As a regulator of food intake, ghrelin also plays a key role in mood disorders. Previous studies reported that acute ghrelin administration defends against depressive symptoms of chronic stress. However, the effects of long-term ghrelin on…

  7. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function.

    Pharmacological reviews200547 influential citations

    Ghrelin is a 28-amino acid peptide originally isolated from rat stomach and is cleaved from a 117-amino acid precursor. The sequence of the mature peptide from rats and mice differs by two amino acids from that of human ghrelin.…

  8. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors.

    The Journal of clinical endocrinology and metabolism200443 influential citations

    Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHS-R), has been primarily linked to the central neuroendocrine regulation of GH secretion and food intake, although additional peripheral actions of ghrelin have also been…

  9. Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system.

    Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society200942 influential citations

    Immune and neuroendocrine systems have bidirectional communications. Growth hormone (GH) and an orexigenic hormone ghrelin are expressed in various immune cells such as T lymphocytes, B lymphocytes, monocytes and neutrophils. These immune…

  10. Identifying the binding mechanism of LEAP2 to receptor GHSR1a.

    The FEBS journal201939 influential citations

    Liver‐expressed antimicrobial peptide 2 ( LEAP 2) is a highly conserved secretory peptide first isolated in 2003. However, its exact biological functions remained elusive until a recent study identified it as an endogenous antagonist for…

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