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Administration RoutesEvidence & Dosage

Subcutaneous, intramuscular, nasal, oral, topical — bioavailability and safety.

Evidence at a glance

Total studies
974
With abstract
8
Meta / Systematic / RCT
1
Highly cited
2
Publication years
1949–2026

Administration Routes in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Administration Routes

Ranked by influential-citation count and publication year.

  1. A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone.

    Neuropsychopharmacology2002RCT30 influential citations

    Acamprosate and naltrexone have each demonstrated safety and efficacy for alcohol dependence in placebo-controlled clinical trials. There is scientific and clinical interest in evaluating these drugs in combination, given their high…

  2. Comparative pharmacokinetic analysis of curcumin and curcumin O-glucuronide through curcumin nano-gel-based delivery system using liquid chromatogram tandem mass spectrometry.

    Pak J Pharm Sci2026Study

    <h4>Background</h4>Curcumin exhibits limited oral bioavailability owing to its poor solubility and rapid metabolism.<h4>Objectives</h4>To develop a novel curcumin nano-gel (CNG) and evaluate its pharmacokinetics following oral and rectal…

  3. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU.

    Critical care medicine2018

    Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design: Thirty-two international experts, four methodologists, and four critical…

  4. CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016

    MMWR Recommendations and Reports2016

    This guideline provides recommendations for primary care clinicians who are prescribing opioids for chronic pain outside of active cancer treatment, palliative care, and end-of-life care. The guideline addresses 1) when to initiate or…

  5. Pharmacokinetics of a novel formulation of ivermectin after administration to goats

    American Journal of Veterinary Research2006

    <h4>Objective</h4>To evaluate the pharmacokinetics of a novel commercial formulation of ivermectin after administration to goats.<h4>Animals</h4>6 healthy adult goats.<h4>Procedure</h4>Ivermectin (200 microg/kg) was initially administered…

  6. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

    Annals of the Rheumatic Diseases2013

    In this article, the 2010 European League against Rheumatism (EULAR) recommendations for the management of rheumatoid arthritis (RA) with synthetic and biological disease-modifying antirheumatic drugs (sDMARDs and bDMARDs, respectively)…

  7. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.

    Annals of the rheumatic diseases2023

    <h4>Objectives</h4>To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field.<h4>Methods</h4>An international task force was formed and solicited three…

  8. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.

    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports2022n=14

    This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients aged ≥18 years. It updates the CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016…

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Injection Safety

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