ApoBEvidence & Dosage
A better cardiovascular risk metric than LDL-C — modern lipidology.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 42
- Meta / Systematic / RCT
- 0
- Highly cited
- 3
- Publication years
- 1974–2026
ApoB in the context of Longevity
This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to LongevityTop studies on ApoB
Ranked by influential-citation count and publication year.
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E.
Science (New York, N.Y.)1992200 influential citationsApolipoprotein E (apoE) is a ligand for receptors that clear remnants of chylomicrons and very low density lipoproteins. Lack of apoE is, therefore, expected to cause accumulation in plasma of cholesterol-rich remnants whose prolonged…
High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study.
Lancet (London, England)2001n=98,722200 influential citations<h4>Background</h4>Apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) are thought to be better predictors of acute myocardial infarction than total cholesterol and LDL-cholesterol. We investigated whether apoB and apoA-I are…
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
JAMA2017n=46,89149 influential citations<h4>Importance</h4>The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic…
THR-β Agonists vs Incretin Therapies for Noncirrhotic Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Biopsy-Anchored Systematic Review With Grading of Recommendations Assessment, Development and Evaluation (GRADE) Certainty.
Cureus2026n=3,796DMetabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease now targeted by new pharmacotherapies, including the thyroid hormone receptor beta (THR-β) agonist resmetirom, glucagon-like peptide-1 (GLP-1)…
Lipid management in type 2 diabetes and non-HDL-cholesterol: target all atherogenic lipoproteins.
Cardiovascular diabetology2026n=10,497DAtherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality in individuals with diabetes, partly driven by dyslipidemia. While low-density lipoprotein cholesterol (LDL-C) reduction is the primary…
Subtype-specific associations between serum lipid profiles and disease severity in patients with amyotrophic lateral sclerosis.
Biomedical reports2026n=158Amyotrophic lateral sclerosis (ALS) is a heterogeneous neurodegenerative disorder. Notably, the differences in lipid metabolism between bulbar- and limb-onset subtypes of ALS remain unclear, particularly in non-Western populations. The…
Oral PCSK9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial.
Journal of the American College of Cardiology2026n=101<h4>Background</h4>Many adults fail to achieve guideline-directed low-density lipoprotein cholesterol (LDL-C) goals on statin monotherapy, requiring additional nonstatin lipid-lowering medication. Enlicitide, an oral proprotein convertase…
Effect of angiopoietin-like protein 3 inhibitors on lipid profile and other biomarkers: a meta-analysis of randomized controlled trials.
European journal of preventive cardiology2026n=1,254<h4>Aims</h4>Inhibition of angiopoietin-like protein 3 (ANGPTL3) has been proposed as a promising approach to reduce residual cardiovascular risk. We conducted a meta-analysis of randomized controlled trials (RCTs) to provide a…
[Combined Analysis of Dyslipidemia and Tumor Markers for the Diagnosis of Gastric Cancer].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026n=100<h4>Objective</h4>To investigate changes in serum lipid profile parameters combined with tumor markers in gastric cancer (GC) patients and their value in GC screening.<h4>Methods</h4>A total of 100 patients diagnosed with GC at Renji…
Persistent sex differences in cardiovascular disease risk factors: a longitudinal cohort study in youth with type 1 diabetes.
American journal of preventive medicine2026<h4>Introduction</h4>Women with type 1 diabetes (T1D) experience a greater diabetes-related increase in cardiovascular disease (CVD) and mortality risk than men. This study aimed to examine early sex-related differences in CVD risk factors…
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