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Longevity

AMPK ActivatorsEvidence & Dosage

Berberine, alpha‑lipoic acid, energetic stress, and glucose modulation.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
76
Highly cited
50
Publication years
1992–2026

AMPK Activators in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on AMPK Activators

Ranked by influential-citation count and publication year.

  1. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Reprod Biol Endocrinol2023n=169meta132 influential citations

    BACKGROUND: Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects. OBJECTIVE: Inositols have…

  2. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review.

    J Transl Med2024n=811Meta-Analysis103 influential citations

    <h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence…

  3. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.

    Cells2021Systematic Review84 influential citations

    5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism…

  4. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    Front Immunol2022n=2,173meta77 influential citations

    BACKGROUND: Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent…

  5. A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis.

    Int J Mol Sci2025n=28Systematic Review75 influential citations

    Osteoporosis is a prevalent metabolic bone disorder characterized by decreased bone mineral density and increased fracture risk, particularly among aging populations. While conventional pharmacological treatments exist, they often have…

  6. A systematic review on anti-diabetic plant essential oil compounds: Dietary sources, effects, molecular mechanisms, and safety.

    Crit Rev Food Sci Nutr2024Systematic Review72 influential citations

    Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic syndrome defined through the dysfunction of pancreatic β-cells driven by a confluence of genetic and environmental elements. Insulin resistance, mediated by interleukins and other…

  7. Targeting AMPK with Irisin: Implications for metabolic disorders, cardiovascular health, and inflammatory conditions - A systematic review.

    Life Sci2025Systematic Review68 influential citations

    Irisin-based interventions have gained attention for their potential to modulate the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway in various diseases. Physiologically, irisin is a myokine released during physical…

  8. The effect of Berberine on weight loss in order to prevent obesity: A systematic review.

    Biomed Pharmacother2020systematic60 influential citations

    This study provides a critical overview of experimental studies in vitro, in humans, and in animals that evaluated the efficacy of Berberine and its effect on management of obesity and the related metabolic consequences. As a result of…

  9. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Oxid Med Cell Longev2021n=4,158meta60 influential citations

    OBJECTIVE: Rhizoma Coptidis is an herb that has been frequently used in many traditional formulas for the treatment of diabetic mellitus (DM) over thousands of years. Berberine, the main active component of Rhizoma Coptidis, has been…

  10. Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway.

    BMC Cancer2024n=111Systematic Review60 influential citations

    <h4>Background</h4>Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy and have significant adverse effects. Therefore, it is essential to establish…

Frequently asked

What dosage was studied?
• Inositols (myoinositol, D-chiro-inositol, or combinations) (Varied across trials; e.g., myoinositol 1000-4000 mg/day, D-chiro-inositol 600-1200 mg/day, combinations such as MI 1100 mg + DCI 27.6 mg) • Berberine (Not reported) • AICAr (5-Aminoimidazole-4-carboxamide ribonucleoside) (not reported)
Are there safety considerations for AMPK Activators?
• Inositol vs placebo: four studies reported no side effects. • Inositol had fewer side effects than metformin (7% vs 53%). • Reported metformin adverse effects were bloating, nausea, and generalized weakness. • Mild gastrointestinal adverse events were reported.

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Sport-specific workload management — injury prevention.

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10–20 min as an energy boost; longer naps can disrupt sleep.

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