Hallmarks of AgingEvidence & Dosage

Top studies on Hallmarks of Aging

Ranked by influential-citation count and publication year.

1. 01

   Individual differences in the cognitive and neurobiological consequences of normal aging.

   Trends in neurosciences·199282 influential citations

   Defining the neural basis of age-related cognitive dysfunction is a major goal of current research on aging. Compelling evidence from laboratory animals and humans indicates that aging does not inevitably lead to cognitive decline.…

2. 02

   Modulating human aging and age-associated diseases.

   Biochimica et biophysica acta·200915 influential citations

   Population aging is progressing rapidly in many industrialized countries. The United States population aged 65 and over is expected to double in size within the next 25 years. In sedentary people eating Western diets aging is associated…

3. 03

   Physical Activity Improves Cognition and Activities of Daily Living in Adults with Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

   International Journal of Environmental Research and Public Health·2022·n=9456 influential citations

   Objective: The purpose of this meta-analysis was to examine the effects of physical activity (PA) on cognition and activities of daily living in adults with Alzheimer’s Disease (AD). Methods: Six electronic databases (MEDLINE, CINAHL,…

4. 04

   The demographic and biomedical case for late-life interventions in aging.

   Science translational medicine·20104 influential citations

   The social and medical costs of the biological aging process are high and will rise rapidly in coming decades, creating an enormous challenge to societies worldwide. In recent decades, researchers have expanded their understanding of the…

5. 05

   The effects of chronic and acute physical activity on working memory performance in healthy participants: a systematic review with meta-analysis of randomized controlled trials

   Systematic Reviews·20173 influential citations

   <h4>Background</h4>Understanding how physical activity (PA) influences cognitive function in populations with cognitive impairments, such as dementia, is an increasingly studied topic yielding numerous published systematic reviews. In…

6. 06

   The Effect of Aerobic Exercise on Cognitive Function in People with Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

   International Journal of Environmental Research and Public Health·2022·n=5033 influential citations

   A growing body of research has examined the effect of aerobic exercise on cognitive function in people with Alzheimer’s Disease (AD), but the findings of the available studies were conflicting. The aim of this study was to explore the…

7. 07

   The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis

   Journal of Clinical Medicine·20202 influential citations

   Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained…

8. 08

   Effects of combined cognitive and physical intervention on enhancing cognition in older adults with and without mild cognitive impairment: A systematic review and meta-analysis

   Frontiers in Aging Neuroscience·20222 influential citations

   Background Combined cognitive and physical intervention is commonly used as a non-pharmacological therapy to improve cognitive function in older adults, but it is uncertain whether combined intervention can produce stronger cognitive gains…

9. 09

   Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation.

   Proceedings of the National Academy of Sciences of the United States of America·20262 influential citations

   Cellular rejuvenation through transcriptional reprogramming is an exciting approach to counter aging. Using a fibroblast-based model of human cell aging and Perturb-seq screening, we developed a systematic approach to identify single…

10. 10

    From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease.

    Journal of neurochemistry·20262 influential citations

    The traditional neuron-centric view of neurodegeneration is being replaced by a glial network-based framework. This shift recognizes that age-related dysfunction in non-neuronal cells critically shapes neuronal vulnerability and circuit…