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Longevity

AutophagyEvidence & Dosage

Cellular self-clearance — fasting, exercise, spermidine as triggers.

Evidence at a glance

Total studies
1,000
With abstract
47
Meta / Systematic / RCT
0
Highly cited
11
Publication years
1977–2026

Autophagy in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Autophagy

Ranked by influential-citation count and publication year.

  1. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

    Nature genetics2004200 influential citations

    Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in intracellular aggregates. Here we show that mammalian target of…

  2. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.

    The EMBO journal2007200 influential citations

    Autophagy is a major catabolic pathway by which eukaryotic cells degrade and recycle macromolecules and organelles. This pathway is activated under environmental stress conditions, during development and in various pathological situations.…

  3. Protein turnover via autophagy: implications for metabolism.

    Annual review of nutrition2007141 influential citations

    Autophagy is a process of cellular "self-eating" in which portions of cytoplasm are sequestered within double-membrane cytosolic vesicles termed autophagosomes. The autophagosome cargo is delivered to the lysosome, broken down, and the…

  4. Autophagy and aging: the importance of maintaining "clean" cells.

    Autophagy2005141 influential citations

    A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related…

  5. TOR-dependent control of autophagy: biting the hand that feeds.

    Current opinion in cell biology201046 influential citations

    Induction of autophagy in response to starvation is a highly conserved ability of eukaryotic cells, indicating a crucial and ancient role of this process in adapting to nutrient conditions. The target of rapamycin (TOR) pathway is major…

  6. Chaperone-mediated autophagy: selectivity pays off.

    Trends in endocrinology and metabolism: TEM201042 influential citations

    Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic…

  7. Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target.

    International journal of molecular sciences2022n=832D39 influential citations

    Metabolic associated fatty liver disease (MAFLD) is one of the most common causes of chronic liver disease worldwide. To date, there is no FDA-approved treatment, so there is an urgent need to determine its pathophysiology and underlying…

  8. Curcumin targets YAP1 to enhance mitochondrial function and autophagy, protecting against UVB-induced photodamage.

    Front Immunol2025n=5Study39 influential citations

    BACKGROUND: Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin damage via DNA damage, oxidative stress, inflammation, and collagen degradation. It penetrates the epidermis, disrupts DNA integrity, and…

  9. Autophagy: a necessary evil in cancer and inflammation.

    202428 influential citations

    Autophagy, a highly regulated cellular process, assumes a dual role in the context of cancer. On the one hand, it functions as a crucial homeostatic pathway, responsible for degrading malfunctioning molecules and organelles, thereby…

  10. Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy.

    J Cell Biochem2023Study12 influential citations

    Elsinochrome A (EA) is a perylene quinone natural photosensitizer, photosensitizer under light excitation generates reactive oxygen species (ROS) to induce apoptosis, so can be used for treating tumors, that is so-called photodynamic…

Frequently asked

Which population does the evidence apply to?
Most studies investigated: animal; unknown.
Are there safety considerations for Autophagy?
• Verteporfin blocked curcumin's protective effects in mechanistic assays. • No adverse events were reported for curcumin or UVB protocols. • UVB exposure itself caused marked skin and cellular injury in both models. • Not reported.

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