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HMBEvidence & Dosage

Sarcopenia, Anti-Catabolic, and Sports Applications

Studies last updated

Evidence at a glance

Total studies
376
With abstract
48
Meta / Systematic / RCT
125
Highly cited
50
Publication years
1996–2026

HMB in the context of Performance

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Top studies on HMB

Ranked by influential-citation count and publication year.

  1. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS).

    Age Ageing2014Systematic Review200 influential citations

    <h4>Objective</h4>to examine the clinical evidence reporting the prevalence of sarcopenia and the effect of nutrition and exercise interventions from studies using the consensus definition of sarcopenia proposed by the European Working…

  2. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses.

    Nutr Rev2021n=15meta177 influential citations

    CONTEXT: Sarcopenia is a progressive and generalized skeletal muscle disorder associated with an increased risk of adverse outcomes such as falls, disability, and death. The Belgian Society of Gerontology and Geriatrics has developed…

  3. The Prevalence of Menstrual Cycle Disorders and Menstrual Cycle-Related Symptoms in Female Athletes: A Systematic Literature Review.

    Sports Med2023n=638Systematic Review156 influential citations

    <h4>Background</h4>Menstrual cycle (MC) disorders and MC-related symptoms can have debilitating effects on the health and performance of female athletes. As the participation of women in sports continues to increase, understanding the…

  4. Heavy menstrual bleeding and dysmenorrhea in adolescents: A systematic review of self-management strategies, quality of life, and unmet needs.

    Int J Gynaecol Obstet2024n=55Systematic Review95 influential citations

    <h4>Background</h4>Heavy menstrual bleeding (HMB) and dysmenorrhea (DM) are common gynecological problems.<h4>Objective</h4>To systematically review the needs, quality of life (QOL), and effectiveness of self-management strategies among…

  5. Time-restricted feeding plus resistance training in active females: a randomized trial.

    Am J Clin Nutr2019n=40RCT86 influential citations

    <h4>Background</h4>A very limited amount of research has examined intermittent fasting (IF) programs, such as time-restricted feeding (TRF), in active populations.<h4>Objective</h4>Our objective was to examine the effects of TRF, with or…

  6. β-Hydroxy-β-methylbutyrate and its impact on skeletal muscle mass and physical function in clinical practice: a systematic review and meta-analysis.

    Am J Clin Nutr2019n=213Meta-Analysis80 influential citations

    <h4>Background</h4>Loss of skeletal muscle mass and muscle weakness are common in a variety of clinical conditions with both wasting and weakness associated with an impairment of physical function. β-Hydroxy-β-methylbutyrate (HMB) is a…

  7. An Overview of Sarcopenia: Focusing on Nutritional Treatment Approaches.

    Nutrients2025review63 influential citations

    Sarcopenia is a syndrome characterized by the progressive and generalized loss of skeletal muscle mass and strength. This condition is associated with physical disability, decreased quality of life, and increased mortality. Therefore,…

  8. Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis.

    Cochrane Database Syst Rev2022n=4,284Meta-Analysis61 influential citations

    <h4>Background</h4>Heavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the absolute amount of bleeding. It is a very common condition in women of reproductive age,…

    Finding: Among second-line treatments, hysterectomy is the best treatment for reducing bleeding, followed by REA and NREA.

  9. Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial.

    Maturitas2017n=107RCT60 influential citations

    <h4>Background and objectives</h4>Functional deterioration and reduced mobility in elderly patients with a hip fracture are associated with a loss of both muscle mass and function (sarcopenia). The aim of this study was to assess whether…

  10. Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis.

    Arch Gerontol Geriatr2015Meta-Analysis56 influential citations

    <h4>Background</h4>Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the branched-chain amino acid leucine, has been investigated as a potential supplement to improve muscle quality; however, whether HMB supplementation has…

Frequently asked

What dosage was studied?
• Nutritional supplementation interventions: proteins, essential amino acids, leucine, β-hydroxy-β-methylbutyrate, creatine, and multinutrient supplementation, with or without physical exercise • Assessment of menstrual cycle disorders and menstrual cycle-related symptoms
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for HMB?
• Not reported in the abstract. • No adverse events reported; review of symptom prevalence only. • Medication and herbal remedy doses were not reported. • Common symptoms included pelvic pain, diarrhea, nausea, and sleep issues.

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