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Testosterone BoostersEvidence & Dosage

What works (sleep, strength training), what doesn't (most supplements).

Evidence at a glance

Total studies
313
With abstract
49
Meta / Systematic / RCT
1
Highly cited
50
Publication years
1976–2026

Testosterone Boosters in the context of Hormones

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Top studies on Testosterone Boosters

Ranked by influential-citation count and publication year.

  1. Effects of testosterone supplementation in the aging male.

    The Journal of clinical endocrinology and metabolism1992200 influential citations

    Serum androgen levels decline with aging in normal males, such that a significant number of men over 60 yr of age will have a mean serum total testosterone (T) level near the low end of the normal adult range. It is not known whether lower…

  2. Validation of a screening questionnaire for androgen deficiency in aging males.

    Metabolism: clinical and experimental2000n=21153 influential citations

    It is now well established that testosterone levels decline with age. What has not been established is whether the decline in testosterone is associated with a symptom complex. This study examined whether certain symptoms are more commonly…

  3. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men.

    The Journal of clinical endocrinology and metabolism2004n=27138 influential citations

    Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the…

  4. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T.

    The Journal of clinical endocrinology and metabolism2005124 influential citations

    Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass. These changes might improve physical performance and strength; however, it has not been established whether T therapy improves…

  5. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle.

    The Journal of clinical endocrinology and metabolism2005n=60116 influential citations

    Although testosterone levels and muscle mass decline with age, many older men have serum testosterone level in the normal range, leading to speculation about whether older men are less sensitive to testosterone. We determined the…

  6. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms.

    American journal of physiology. Endocrinology and metabolism2002n=7114 influential citations

    We investigated the effects of 6 mo of near-physiological testosterone administration to older men on skeletal muscle function and muscle protein metabolism. Twelve older men (> or =60 yr) with serum total testosterone concentrations <17…

  7. Testosterone supplementation improves spatial and verbal memory in healthy older men.

    Neurology200196 influential citations

    <h4>Objective</h4>To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men.<h4>Background</h4>Serum levels of total and bioavailable testosterone gradually…

  8. Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone.

    The Journal of clinical endocrinology and metabolism200496 influential citations

    Older men, particularly those with low serum testosterone (T) levels, might benefit from T therapy to improve bone mineral density (BMD) and reduce fracture risk. Concerns exist, however, about the impact of T therapy on the prostate in…

  9. Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels.

    The journals of gerontology. Series A, Biological sciences and medical sciences2001n=4495 influential citations

    <h4>Background</h4>A large proportion of men over 65 years of age have bioavailable testosterone levels below the reference range of young adult men. The impact of this on musculoskeletal health and the potential for improvement in…

  10. AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function.

    The Journal of clinical endocrinology and metabolism200394 influential citations

    Testosterone replacement in hypogonadal men improves body composition, mood, and sexual functioning. In this 90-d study, we compared the pharmacokinetics and treatment effectiveness of a topical testosterone gel (AA2500) at two…

Frequently asked

Are there safety considerations for Testosterone Boosters?
• Frequency of hematocrit greater than 54%, leg edema, and prostate events were numerically higher in older men than in young men.

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