GhrelinEvidence & Dosage
Hunger hormone, sleep's influence, intermittent-fasting adaptation.
Evidence at a glance
- Total studies
- 906
- With abstract
- 47
- Meta / Systematic / RCT
- 0
- Highly cited
- 24
- Publication years
- 1996–2026
Ghrelin in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Ghrelin
Ranked by influential-citation count and publication year.
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
Nature1999200 influential citationsSmall synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of…
A role for ghrelin in the central regulation of feeding.
Nature2001200 influential citationsGhrelin is an acylated peptide that stimulates the release of growth hormone from the pituitary. Ghrelin-producing neurons are located in the hypothalamus, whereas ghrelin receptors are expressed in various regions of the brain, which is…
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.
Diabetes2001200 influential citationsThe recently discovered orexigenic peptide ghrelin is produced primarily by the stomach and circulates in blood at levels that increase during prolonged fasting in rats. When administered to rodents at supraphysiological doses, ghrelin…
Ghrelin enhances appetite and increases food intake in humans.
The Journal of clinical endocrinology and metabolism2001200 influential citationsGhrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in the circulation of healthy humans. Ghrelin has been shown to promote increased…
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
The New England journal of medicine2002200 influential citations<h4>Background</h4>Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive…
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
Endocrinology2000200 influential citationsGhrelin, a novel 28 amino acid peptide found in hypothalamus and stomach, was recently identified as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R). We have now found that both intracerebroventricular (i.c.v.)…
The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.
The Journal of clinical endocrinology and metabolism2002200 influential citationsGhrelin is a novel growth hormone-releasing peptide, originally identified in the rat stomach as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R1a). Ghrelin is involved in the regulation of GH release, but it has…
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
The Journal of clinical endocrinology and metabolism2002200 influential citationsGhrelin, a novel GH-releasing peptide isolated from human and rat stomach, stimulates food intake and GH secretion. We determined plasma ghrelin concentrations in patients with simple obesity, anorexia nervosa, and type 2 diabetes mellitus…
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.
The Journal of clinical endocrinology and metabolism2001200 influential citationsGhrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat stomach and is involved in a novel system for regulating GH release. Although previous studies in rodents suggest that ghrelin is also involved in energy…
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.
Endocrine reviews2004200 influential citationsGhrelin is a peptide predominantly produced by the stomach. Ghrelin displays strong GH-releasing activity. This activity is mediated by the activation of the so-called GH secretagogue receptor type 1a. This receptor had been shown to be…
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