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Cortisol Daily ProfileEvidence & Dosage

The diurnal rhythm, CAR (cortisol awakening response), saliva measurement.

Evidence at a glance

Total studies
797
With abstract
50
Meta / Systematic / RCT
0
Highly cited
29
Publication years
1967–2026

Cortisol Daily Profile in the context of Hormones

This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Cortisol Daily Profile

Ranked by influential-citation count and publication year.

  1. Cortisol levels during human aging predict hippocampal atrophy and memory deficits.

    Nature neuroscience1998200 influential citations

    Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats. Previously we related persistent cortisol increases to memory impairments in elderly humans studied…

  2. Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development.

    Development and psychopathology2001200 influential citations

    Since the work of Hans Selye, stress has been associated with increased activity of the limbic-hypothalamic-pituitary-adrenocortical (LHPA) axis. Recently, a number of studies in adults have shown that this neuroendocrine axis may be…

  3. A.E. Bennett Research Award. Developmental traumatology. Part I: Biological stress systems.

    Biological psychiatry1999n=24164 influential citations

    <h4>Background</h4>This investigation examined the relationship between trauma, psychiatric symptoms and urinary free cortisol (UFC) and catecholamine (epinephrine [EPI], norepinephrine [NE], dopamine [DA]) excretion in prepubertal…

  4. Dynamics and correlation of serum cortisol and corticosterone under different physiological or stressful conditions in mice.

    PloS one2015n=6146 influential citations

    Although plasma corticosterone is considered the main glucocorticoid involved in regulation of stress responses in rodents, the presence of plasma cortisol and whether its level can be used as an indicator for rodent activation of stress…

  5. Decreased memory performance in healthy humans induced by stress-level cortisol treatment.

    Archives of general psychiatry1999n=51123 influential citations

    <h4>Background</h4>Glucocorticoids (GCs) can regulate hippocampal metabolism, physiologic functions, and memory. Despite evidence of memory decreases during pharmacological GC treatment, and correlations between memory and cortisol levels…

  6. Low salivary cortisol and persistent aggression in boys referred for disruptive behavior.

    Archives of general psychiatry2000104 influential citations

    <h4>Background</h4>Persistent antisocial behavior in adulthood is often preceded by childhood-onset aggressive conduct disorder. Aggressive syndromes in both children and adults have previously been associated with abnormalities in…

  7. Biology of posttraumatic stress disorder.

    J Clin Psychiatry2001review96 influential citations

    Most biological findings in posttraumatic stress disorder (PTSD) are compatible with those of the chronic stress response, such as increased corticotropin-releasing factor (CRF) concentrations, catecholamine depletion within the central…

  8. Association between time of awakening and diurnal cortisol secretory activity.

    Psychoneuroendocrinology2001n=4089 influential citations

    A 12-hour diurnal profile of salivary free cortisol was measured in healthy adults (n=40) on two consecutive days. Samples were collected at timed intervals synchronised to awakening. The mean profile is characterised by a marked increase…

  9. Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity.

    Life sciences200184 influential citations

    Adrenocortical activity can be assessed by measurement of free cortisol in saliva. Cortisol status has important health implications in both physical and psychological terms. Assessment of cortisol status is complicated by the marked…

  10. Relationship functioning and home and work demands predict individual differences in diurnal cortisol patterns in women.

    Psychoneuroendocrinology200170 influential citations

    In 70 middle-class mothers of 2-year-old children, individual differences in mothers' morning cortisol levels, cortisol decreases across the day and average cortisol levels were predicted from demographic and medical control variables,…

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