Adrenal FatigueEvidence & Dosage

Top studies on Adrenal Fatigue

Ranked by influential-citation count and publication year.

1. 01

   A randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgia.

   J Rheumatol·2005RCT13 influential citations

   <h4>Objective</h4>Patients with fibromyalgia (FM) consistently have adrenal hyporesponsiveness and low dehydroepiandrosterone (DHEA) levels. DHEA is promoted for and used by patients with FM. We tested the efficacy and safety of DHEA…

2. 02

   Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study.

   Am J Clin Nutr·2025·n=51RCT2 influential citations

   <h4>Background</h4>Subclinical depressive symptoms, including low mood, fatigue and anxiety, refer to clinically relevant depressive manifestations that do not meet the criteria for major depressive disorder. These symptoms affect quality…

3. 03

   Clinical characteristics and management of PD-1/PD-L1 inhibitor-induced secondary adrenal insufficiency.

   Endocrine connections·2026·n=75E

   Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors significantly improve outcomes in multiple malignancies; however, they can induce immune-related endocrine adverse events, such as secondary adrenal insufficiency…

4. 04

   Muscle pain in a woman with congenital adrenal hyperplasia due to 21-hydroxylase deficiency resolved with testosterone therapy. A case report with 10 years of follow-up.

   Frontiers in endocrinology·2026E

   Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) requires lifelong glucocorticoid (GC) and mineralocorticoid therapy to prevent adrenal crises and control androgen excess. However, chronic GC overtreatment may…

5. 05

   Case report and literature review: isolated ACTH deficiency induced by combined nivolumab and trastuzumab therapy in gastric adenocarcinoma.

   Frontiers in endocrinology·2026D

   Isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is an uncommon endocrine disorder characterised by the selective reduction or absence of pituitary ACTH secretion, resulting in secondary adrenal insufficiency while other…

6. 06

   Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity.

   Mol Psychiatry·2026·n=138Systematic Review

   Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a major clinical challenge as a complex multisystemic disorder with no well-established pathophysiological mechanism, characterized by persistent fatigue and post-exertional…

7. 07

   Adrenal insufficiency

   The Lancet·2003

   Adrenal insufficiency is caused by either primary adrenal failure (mostly due to autoimmune adrenalitis) or by hypothalamic-pituitary impairment of the corticotropic axis (predominantly due to pituitary disease). It is a rare disease, but…

8. 08

   Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome

   The Journal of Clinical Endocrinology & Metabolism·1991

   Chronic fatigue syndrome is characterized by persistent or relapsing debilitating fatigue for at least 6 months in the absence of a medical diagnosis that would explain the clinical presentation. Because primary glucocorticoid deficiency…

9. 09

   Posttraumatic Stress Disorder and Physical Illness: Results from Clinical and Epidemiologic Studies

   Annals of the New York Academy of Sciences·2004

   Research indicates that exposure to traumatic stressors and psychological trauma is widespread. The association of such exposures with posttraumatic stress disorder (PTSD) and other mental health conditions is well known. However,…

10. 10

    Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment.

    PubMed·2005

    Fibromyalgia syndrome (FM) is a common chronic pain condition that affects at least 2% of the adult population in the USA and other regions in the world where FM is studied. Prevalence rates in some regions have not been ascertained and…

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