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Growth Hormone (GH/IGF-1)Evidence & Dosage

Sleep secretion, secretagogues and IGF-1 as biomarker

Studies last updated

Evidence at a glance

Total studies
629
With abstract
50
Meta / Systematic / RCT
135
Highly cited
50
Publication years
1989–2026

Growth Hormone (GH/IGF-1) in the context of Hormones

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Top studies on Growth Hormone (GH/IGF-1)

Ranked by influential-citation count and publication year.

  1. New insights on the cardiovascular effects of IGF-1.

    Front Endocrinol (Lausanne)2023n=4,000Systematic Review99 influential citations

    Introduction Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV health Methods We…

  2. Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis.

    Rev Endocr Metab Disord2025n=409Meta-Analysis66 influential citations

    Pasireotide long-acting release (PAS-LAR) is a second-generation somatostatin receptor ligand (SRL) approved for acromegaly treatment. This meta-analysis aimed to evaluate the real-world effectiveness and safety of PAS-LAR in patients with…

    Finding: In this real-world meta-analysis, pasireotide long-acting release achieved IGF-1 control in 57.9% of patients with acromegaly.

  3. Efficacy, safety, quality of life, adherence and cost-effectiveness of long-acting growth hormone replacement therapy compared to daily growth hormone in children with growth hormone deficiency: A systematic review and meta-analysis.

    Pharmacol Res2023n=16Meta-Analysis65 influential citations

    We evaluated the efficacy, safety, adherence, quality of life (QoL) and cost-effectiveness of long-acting growth hormone (LAGH) vs daily growth hormone (GH) preparations in the treatment of growth hormone deficiency (GHD) in children.…

  4. The influence of growth hormone on pediatric body composition: A systematic review.

    Front Endocrinol (Lausanne)2023n=16Systematic Review57 influential citations

    Background Growth hormone (GH) affects metabolism and regulates growth in childhood. The most prominent feature of GH deficiency (GHD) in children is diminished height velocity that eventually leads to short stature. In adult-onset GHD,…

  5. GH Therapy in Chronic Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

    J Clin Endocrinol Metab2025n=355Meta-Analysis50 influential citations

    <h4>Context</h4>Guideline-directed medical therapy of heart failure (HF) primarily targets neurohormonal activation. However, GH has emerged as a potential treatment for the multiple hormonal deficiency syndrome, which is associated with…

  6. The influence of growth and sex hormones on risk of alzheimer's disease: a mendelian randomization study.

    Eur J Epidemiol2023n=21,982Meta-Analysis47 influential citations

    Alzheimer's disease is more prevalent in women, possibly due to sex or growth hormones but existing evidence is inconclusive. We investigated whether genetically predicted sex and growth hormones are associated with risk of Alzheimer's…

  7. Identifying Potentially Modifiable Factors Associated with Treatment Non-Adherence in Paediatric Growth Hormone Deficiency: A Systematic Review.

    Horm Res Paediatr2018Systematic Review44 influential citations

    <b><i>Background:</i></b> Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail…

  8. Pegvisomant Improves Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies.

    J Clin Endocrinol Metab2019n=550Meta-Analysis40 influential citations

    <h4>Introduction</h4>Pegvisomant (PEG) in monotherapy or combined with somatostatin analogs (SSAs) is used to control acromegaly, improving metabolism. However, the metabolic changes induced by PEG have not been systematically…

    Finding: In patients with acromegaly, pegvisomant significantly decreased fasting plasma glucose, HbA1c, fasting plasma insulin, and HOMA-I.

  9. The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis.

    Complement Ther Med2020n=33Meta-Analysis40 influential citations

    <h4>Background</h4>Data about the effects of resistance exercise on level of IGF-1 in the serum are conflicting. To resolve this inconsistency, we performed a systematic review and meta-analysis to precisely examine the effects of…

  10. Treatment Adherence to Injectable Treatments in Pediatric Growth Hormone Deficiency Compared With Injectable Treatments in Other Chronic Pediatric Conditions: A Systematic Literature Review.

    Front Endocrinol (Lausanne)2022n=23Systematic Review36 influential citations

    Background Pediatric patients with growth hormone deficiency (GHD) are currently treated with daily injections of recombinant human growth hormone (rhGH) to promote linear growth and enable attainment of normal adult height. One of the…

Frequently asked

What dosage was studied?
• IGF-1-related therapy / IGF axis targeting (not reported) • Pasireotide long-acting release (PAS-LAR) (Not reported) • Long-acting growth hormone (LAGH) preparations: Eutropin Plus, Jintrolong, Somatrogon, TransCon (Not reported)
Are there safety considerations for Growth Hormone (GH/IGF-1)?
• The review anticipates novel IGF-1-related therapy with minimal side effects, but no specific adverse events are reported. • Glucose metabolism worsened after PAS-LAR. • HbA1c increased after treatment. • T2DM prevalence increased after treatment.

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