Ashwagandha (Sleep)Evidence & Dosage
Cortisol lowering, sleep quality — KSM-66 and Sensoril extracts.
Evidence at a glance
- Total studies
- 13
- With abstract
- 13
- Meta / Systematic / RCT
- 0
- Highly cited
- 4
- Publication years
- 1993–2025
Ashwagandha (Sleep) in the context of Sleep
This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to SleepTop studies on Ashwagandha (Sleep)
Ranked by influential-citation count and publication year.
Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses.
Cancer letters200818 influential citationsAshwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general…
Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A.
Neurochemical research201213 influential citationsIn the present study we investigate the effect of Withania somnifera (WS) root extract and Withanolide A (WA) in restoring spatial memory deficit by inhibiting oxidative stress induced alteration in glutamergic neurotransmission. We…
Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180.
Indian journal of experimental biology199311 influential citationsAntitumor and radiosensitizing effects of alcoholic root extract of W. somnifera and their modification by heat were studied in vivo on Sarcoma-180 grown on the dorsum of adult BALB/c mouse. Ashwagandha (AT) was injected (ip) at a dose of…
Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled, Two-Armed Cross-Over Study.
Pharmaceuticals (Basel, Switzerland)2020n=157E9 influential citationsThe current and potential uses of adaptogens are mainly related to treatment of stress-induced fatigue, impaired cognitive function, mental illness, and behavioral- and age-related disorders. However, clinical evidence regarding the…
Nootropic-like effect of ashwagandha (Withania somnifera L.) in mice.
Phytotherapy research : PTR2001Ashwagandha (Withania somnifera L.) root extract (50, 100 and 200 mg/kg; orally) improved retention of a passive avoidance task in a step-down paradigm in mice. Ashwagandha (50, 100 and 200 mg/kg; orally) also reversed the scopolamine (0.3…
DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera (Ashwagandha).
Current research in toxicology2021<i>Withania somnifera,</i> commonly known as Ashwagandha, is a medicinal plant used for thousands of years for various remedies. Extracts of Ashwagandha contain more than 200 metabolites, with withanone (win) being one of the major ones…
Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line.
The Journal of international medical research2018Objective To evaluate the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract against a hepatocellular carcinoma cell line. Methods After treating HepG2cells with Ashwagandha water extract (ASH-WX;…
Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer
Current Issues in Molecular Biology2024The aim of this review is to provide experimental evidence for the programmed-death activity of Ashwagandha (<i>Withania somnifera</i>) in the anti-cancer therapy of breast cancer. The literature search was conducted using online…
The Synergistic and Anticancer Potential of Withania Somnifera (Ashwagandha) Ethanol Extract as an Adjuvant with Doxorubicin in MCF7 Breast Cancer Cell Line.
Asian Pacific journal of cancer prevention : APJCP2025n=3ERecent approaches in breast cancer treatment involve exploring natural extracts either as substitutes for traditional chemotherapeutic agents or as adjuvants to enhance their effectiveness. In this context, ethanolic extracts from Withania…
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and reverse pharmacophore analysis
Journal of Biological Engineering2024Cerebroside sulfotransferase (CST) is considered as therapeutic target for substrate reduction therapy (SRT) for metachromatic leukodystrophy (MLD). The present study evaluates the therapeutic potential of 57 phytoconstituents of Withania…
More topics in Sleep
Glycine
Glycine, sleep quality, body temperature and safety.
Alcohol & Sleep
Faster sleep onset, but REM suppression and night-time waking.
Antihistamines
Diphenhydramine, doxylamine — sleep fragmentation, anticholinergic dementia risks.
Apigenin
Chamomile, GABA modulation, and sleep quality.
Apigenin (Sleep)
A flavonoid from chamomile, GABA modulation, sleep quality.
Bedroom Darkness
Blackout curtains, sleep mask — melatonin and sleep depth.
Bedroom Temperature
Optimal 17–19°C — a falling core body temperature promotes sleep.
Benzodiazepines
Sedative/hypnotic — dependence, cognitive risks in older age.
Blue Light Filter
f.lux, Night Shift, glasses — the evidence and the marketing hype.
Bruxism
Teeth grinding — stress, night guard, trigger factors.
Caffeine Timing
Half-life ~5–6h — cut off 8–10h before sleep.
CBD for Sleep
Endocannabinoid system, REM effects, and dosage spectrum.
CBT-I
Cognitive behavioral therapy for insomnia — first-line therapy per the guidelines.
Circadian Rhythm
The internal ~24h clock — light as the main signal, peripheral clocks in the organs.
CPAP
Continuous positive airway pressure — the standard for moderate apnea.
Deep Sleep
N3 slow-wave sleep — physical recovery, GH release.
GABA Supplements
Blood-brain barrier, fermented GABA, and efficacy data.
Glycine for Sleep
Deep sleep, lowering body temperature, and 3 g in the evening.
Glycine (Sleep)
3g before bed — lowers core body temperature, modulates deep sleep.
Glymphatic System
The brain's overnight detox — beta-amyloid clearance.
Related topics from other worlds
Warm-up
The RAMP protocol, dynamic stretching, neural activation.
Contrast Therapy
Alternating heat and cold — a vascular workout.
Ginger
6-gingerol, nausea, anti-inflammatory, relevance for sport.
Overtraining
Early warning signs, diagnosis, recovery strategies, hormone markers.
Stretching
Static vs. dynamic — timing, effects on performance and injury.
Animal vs Human Studies
Mouse ≠ human — translatability from resveratrol to rapamycin is shaky.