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Caffeine TimingEvidence & Dosage

Half-life ~5–6h — cut off 8–10h before sleep.

Evidence at a glance

Total studies
60
With abstract
28
Meta / Systematic / RCT
0
Highly cited
0
Publication years
2014–2026

Caffeine Timing in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Caffeine Timing

Ranked by influential-citation count and publication year.

  1. Timing of vasopressin initiation influences renal outcomes in mixed cardiogenic-vasodilatory shock supported by VA-ECMO

    Anaesthesia Critical Care & Pain Medicine2026n=4802 influential citations

    <h4>Introduction</h4>Mixed cardiogenic-vasodilatory shock carries high mortality. Vasopressin and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are used in refractory cases, but evidence on the optimal timing of vasopressin…

  2. Timing of Debridement, Antibiotics, and Implant Retention Within 48 Hours for Acute Knee Periprosthetic Joint Infection May Not Improve Success Rate

    The Journal of Arthroplasty2026n=1661 influential citations

    <h4>Background</h4>Debridement, antibiotics, and implant retention (DAIR) is a common first-line treatment for acute periprosthetic joint infection (PJI) following total knee arthroplasty (TKA). However, the optimal timing for DAIR remains…

  3. Adverse childhood experiences and late-life depression in Korea: The role of developmental timing and gender-specific vulnerability

    Journal of Affective Disorders2026

    <h4>Background</h4>This study examined the association between adverse childhood experiences (ACEs) and depressive symptoms among older adults in South Korea and explored variation by exposure timing and gender.<h4>Methods</h4>We analyzed…

  4. Effect of Performance Feedback Timing on Motor Learning for a Surgical Training Task

    IEEE Transactions on Biomedical Engineering2026

    <h4>Objective</h4>Robot-assisted minimally invasive surgery (RMIS) has become the gold standard for a variety of surgical procedures, but the optimal method of training surgeons for RMIS is unknown. We hypothesized that real-time, rather…

  5. Exploring Which of Timing or Accumulation of Physical Activity During Adolescence Better Predicts Physical Activity in Early Adulthood

    Journal of Physical Activity and Health2026n=530

    Background : Adolescence is key for developing physical activity (PA) habits that persist into adulthood. However, whether the timing of adolescent PA matters remains unclear. This study compares the timing versus cumulative exposure to…

  6. Association between selective serotonin reuptake inhibitors and 28-day in-hospital mortality in critically ill patients with depression: A cohort study stratified by exposure timing

    Journal of Affective Disorders2026n=8,033

    <h4>Background</h4>Selective serotonin reuptake inhibitors (SSRIs) have reported immunomodulatory effects. Whether SSRI exposure is associated with short-term survival among critically ill patients with comorbid depression, and whether…

  7. Timing of cardiogenic shock and clinical outcomes in takotsubo syndrome: A multicenter cohort study

    International Journal of Cardiology2026n=191

    <h4>Background</h4>Takotsubo syndrome (TTS) may be complicated by cardiogenic shock (CS), a life-threatening condition that worsens prognosis. Whether the timing of CS onset-at admission or during hospitalization-provides prognostic…

  8. Timing of Tracheostomy in Critically Ill Geriatric Trauma Patients: A Nationwide Analysis

    Journal of Surgical Research2026n=3,501

    <h4>Introduction</h4>Tracheostomy is frequently performed in trauma patients requiring prolonged mechanical ventilation. The optimal timing in older people, with limited physiologic reserve, remains unclear. Our study aims to evaluate…

  9. How Timing of Regional Anesthesia Impacts Outcomes in Traumatic Rib Fracture Patients: A Trauma Quality National Improvement Program–Based Study

    Journal of Surgical Research2026

    <h4>Introduction</h4>Rib fractures are a common traumatic injury with significant morbidity and mortality. Management requires adequate pain control, often requiring the addition of regional anesthesia (RA), such as peripheral nerve blocks…

  10. The influence of burn injury timing on survival in patients with severe burns

    Injury2026n=6,152

    <h4>Introduction</h4>Various factors can influence the survival of patients with severe burns. One of these factors could be the day or time of the burn injury. There are studies describing worse outcomes and higher mortality, as well as…

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