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ApigeninEvidence & Dosage

Chamomile, GABA modulation, and sleep quality.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
30
Highly cited
34
Publication years
1972–2026

Apigenin in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Apigenin

Ranked by influential-citation count and publication year.

  1. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.

    Nutrients2020n=38Systematic Review141 influential citations

    The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects,…

  2. Citrus flavonoids as potential therapeutic agents: A review.

    Phytother Res2022Systematic Review114 influential citations

    The plants Rutaceae family are known to have contributed a lot toward food and medicine. The most important metabolites of the family are flavonoids. A systematic review was conducted to collect chemical and pharmacological information of…

  3. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug.

    J Ethnopharmacol2024Meta-Analysis79 influential citations

    <h4>Ethnopharmacological relevance</h4>Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors of the digestive system. Portulaca oleracea L. (POL), has been used in TCM for…

    Finding: The review suggests that Portulaca oleracea L. compounds may help improve NASH and NASH-HCC.

  4. Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies-An Update Overview.

    Molecules2023Systematic Review74 influential citations

    This review article describes studies published over the past five years on the combination of polyphenols, which are the most studied in the field of anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and…

  5. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review.

    Pharmacol Res2021Systematic Review66 influential citations

    With the coming of the era of the aging population, hypertension has become a global health burden to be dealt with. Although there are multiple drugs and procedures to control the symptoms of hypertension, the management of it is still a…

  6. Apigenin targets fetuin-A to ameliorate obesity-induced insulin resistance.

    International journal of biological sciences2024n=7E61 influential citations

    Fetuin-A, a hepatokine secreted by hepatocytes, binds to insulin receptors and consequently impairs the activation of the insulin signaling pathway, leading to insulin resistance. Apigenin, a flavonoid isolated from plants, has beneficial…

  7. Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus.

    Naunyn Schmiedebergs Arch Pharmacol2025Systematic Review60 influential citations

    Flavonoids in fruits, vegetables, and plant-based drinks have potential neuroprotective properties, with clinical research focusing on their role in reducing oxidative stress, controlling inflammation, and preventing apoptosis. Some…

  8. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.

    Int J Cancer2007n=66,940Clinical Trial58 influential citations

    Flavonoids are antioxidant compounds found in plants, including fruits, vegetables and tea. No prior prospective studies have examined the association between intake of flavonoids in the flavonol and flavone subclasses and ovarian cancer…

  9. Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models.

    Crit Rev Oncol Hematol2022n=25Meta-Analysis54 influential citations

    <h4>Background</h4>Apigenin is being increasingly recognized as a cancer chemopreventive agent. We aimed to investigate the anticancer effects of Apigenin in in-vivo studies to know its present research status and how close or how far it…

  10. Flavonoids as biopesticides - Systematic assessment of sources, structures, activities and environmental fate.

    Sci Total Environ2022n=201Systematic Review53 influential citations

    Biopesticides obtained from renewable resources and associated with biodegradability have the potential to address resource limitations and environmental pollution, often caused by many conventional pesticides, due to the facility of…

Frequently asked

What dosage was studied?
• Citrus flavonoids (19 compounds, including hesperidin, naringenin, naringin, nobiletin, tangeretin, etc.) (Not reported) • Flavonoids isolated from Citrus/Rutaceae species (not reported) • Portulaca oleracea L. and its active compounds (not reported)
Are there safety considerations for Apigenin?
• Not reported • No adverse events were reported in the abstract. • Intravenous curcumin was reported as safe and well tolerated in one breast cancer trial. • Up to 4 g phosphatidylcholine curcumin was safely administered with irinotecan.

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