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CPAPEvidence & Dosage

Continuous positive airway pressure — the standard for moderate apnea.

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
126
Highly cited
50
Publication years
1975–2026

CPAP in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on CPAP

Ranked by influential-citation count and publication year.

  1. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis.

    JAMA2023n=4,186Meta-Analysis200 influential citations

    Importance The effect of continuous positive airway pressure (CPAP) on secondary cardiovascular disease prevention is highly debated. Objective To assess the effect of CPAP treatment for obstructive sleep apnea (OSA) on the risk of adverse…

  2. Orofacial Myofunctional Therapy for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

    Laryngoscope2024n=310Meta-Analysis130 influential citations

    <h4>Objective</h4>Orofacial myofunctional therapy (OMT) is an alternative form of treatment of obstructive sleep apnea (OSA), that incorporates various exercises to optimize tongue placement and increase oropharyngeal tone. The objective…

  3. Effect of CPAP therapy on blood pressure in patients with obstructive sleep apnoea: a worldwide individual patient data meta-analysis.

    Eur Respir J2025n=943Meta-Analysis117 influential citations

    <h4>Background</h4>Obstructive sleep apnoea (OSA) is associated with hypertension, and OSA treatment can reduce systolic blood pressure (SBP) and diastolic blood pressure (DBP), but with a modest mean effect size and vast heterogeneity…

    Finding: CPAP treatment was associated with blood pressure reduction in patients with uncontrolled office systolic blood pressure only.

  4. Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: A systematic review and meta-analysis.

    Sleep Med Rev2023n=29Meta-Analysis102 influential citations

    Upper airway (UA) collapsibility is one of the key factors that determine the severity of obstructive sleep apnea (OSA). Interventions for OSA are aimed at reducing UA collapsibility, but selecting the optimal alternative intervention for…

  5. High-flow nasal cannula therapy for infants with bronchiolitis.

    Cochrane Database Syst Rev2024n=2,813Meta-Analysis92 influential citations

    <h4>Background</h4>Bronchiolitis is a common lower respiratory tract illness, usually of viral aetiology, affecting infants younger than 24 months of age and is the most common cause of hospitalisation of infants. It causes airway…

  6. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing.

    American journal of respiratory and critical care medicine2004n=6084 influential citations

    Obstructive sleep apnea causes intermittent elevation of systemic blood pressure (BP) during sleep. To determine whether obstructive apnea in children has a tonic effect on diurnal BP, 24-hour ambulatory blood pressure was obtained from 60…

  7. "Nocturia and obstructive sleep apnea syndrome: A systematic review".

    Sleep Med Rev2023Systematic Review82 influential citations

    Lower urinary tract symptoms represent a significant public health problem worldwide, impairing patients' quality of life, especially in elderly people. Among LUTS, nocturia is assessed as the most experienced entity related to several…

  8. Less invasive surfactant administration versus intubation-surfactant-extubation in the treatment of neonatal respiratory distress syndrome: a systematic review and meta-analyses.

    J Pediatr (Rio J)2024n=1,944Meta-Analysis75 influential citations

    <h4>Objectives</h4>To compare LISA with INSURE technique for surfactant administration in preterm with gestational age (GA) < 36 weeks with RDS in respect to the incidence of pneumothorax, bronchopulmonary dysplasia (BPD), need for…

  9. Association of Extubation Failure Rates With High-Flow Nasal Cannula, Continuous Positive Airway Pressure, and Bilevel Positive Airway Pressure vs Conventional Oxygen Therapy in Infants and Young Children: A Systematic Review and Network Meta-Analysis.

    JAMA Pediatr2023n=1,421Meta-Analysis70 influential citations

    Importance Extubation failure (EF) has been associated with worse outcomes in critically ill children. The relative efficacy of different modes of noninvasive respiratory support (NRS) to prevent EF is unknown. Objective To study the…

  10. Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.

    Eur Heart J2026n=354RCT70 influential citations

    <h4>Background and aims</h4>Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular…

Frequently asked

What dosage was studied?
• CPAP treatment for obstructive sleep apnea (OSA) • Orofacial myofunctional therapy (OMT) • Continuous positive airway pressure (CPAP) therapy (Not reported)
Are there safety considerations for CPAP?
• Not reported • Low-risk OSA subgroups showed increased MACCE risk with CPAP vs usual care. • CPAP benefit was limited to high-risk OSA; use in low-risk OSA may be harmful for cardiovascular prevention.

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