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CBD for SleepEvidence & Dosage

Endocannabinoid system, REM effects, and dosage spectrum.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
144
Highly cited
50
Publication years
1975–2026

CBD for Sleep in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on CBD for Sleep

Ranked by influential-citation count and publication year.

  1. Cannabis-based medicines for chronic neuropathic pain in adults.

    Cochrane Database Syst Rev2018n=175Meta-Analysis200 influential citations

    <h4>Background</h4>This review is one of a series on drugs used to treat chronic neuropathic pain. Estimates of the population prevalence of chronic pain with neuropathic components range between 6% and 10%. Current pharmacological…

    Finding: Cannabis-based medicines may increase the number of adults with chronic neuropathic pain who achieve 50% or greater pain relief compared with placebo.

  2. Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis.

    Lancet Psychiatry2019n=306Meta-Analysis200 influential citations

    <h4>Background</h4>Medicinal cannabinoids, including medicinal cannabis and pharmaceutical cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), have been suggested to have a therapeutic…

  3. Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies.

    BMJ2023n=101Systematic Review200 influential citations

    Objective To systematically assess credibility and certainty of associations between cannabis, cannabinoids, and cannabis based medicines and human health, from observational studies and randomised controlled trials (RCTs). Design Umbrella…

  4. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.

    Neurology2005n=66RCT148 influential citations

    <h4>Background</h4>Central pain in multiple sclerosis (MS) is common and often refractory to treatment.<h4>Methods</h4>We conducted a single-center, 5-week (1-week run-in, 4-week treatment), randomized, double-blind, placebo-controlled,…

  5. Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.

    Neuropsychopharmacology2020n=803Meta-Analysis148 influential citations

    Cannabidiol (CBD) is being investigated as a treatment for several medical disorders but there is uncertainty about its safety. We conducted the first systematic review and meta-analysis of the adverse effects of CBD across all medical…

  6. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.

    J Pain Symptom Manage2010n=177RCT147 influential citations

    This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced cancer. In…

  7. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.

    Mult Scler2004n=160RCT123 influential citations

    The objective was to determine whether a cannabis-based medicinal extract (CBME) benefits a range of symptoms due to multiple sclerosis (MS). A parallel group, double-blind, randomized, placebo-controlled study was undertaken in three…

  8. Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review.

    BMC Psychiatry2020n=13Systematic Review121 influential citations

    Background Medicinal cannabis has received increased research attention over recent years due to loosening global regulatory changes. Medicinal cannabis has been reported to have potential efficacy in reducing pain, muscle spasticity,…

  9. Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.

    BMC Med2022n=12,123Meta-Analysis120 influential citations

    Background Medical cannabinoids differ in their pharmacology and may have different treatment effects. We aimed to conduct a pharmacology-based systematic review (SR) and meta-analyses of medical cannabinoids for efficacy, retention and…

  10. Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial.

    Trends Psychiatry Psychother2024n=60RCT114 influential citations

    <h4>Objective</h4>Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived…

Frequently asked

What does the evidence say about CBD for Sleep?
Cannabis-based medicines may increase the number of adults with chronic neuropathic pain who achieve 50% or greater pain relief compared with placebo.
What dosage was studied?
• Cannabis-based medicines (herbal cannabis, plant-derived THC/CBD oromucosal spray, synthetic THC mimic nabilone, plant-derived THC dronabinol) (Not reported) • Medicinal cannabinoids, including medicinal cannabis, pharmaceutical cannabinoids, THC, CBD, and synthetic derivatives (Not reported) • Cannabis, cannabinoids, and cannabis based medicines (Not reported)
Are there safety considerations for CBD for Sleep?
• Withdrawals due to adverse events were higher with cannabis-based medicines than placebo. • Nervous system adverse events were more common with cannabis-based medicines. • Psychiatric disorders were more common with cannabis-based medicines. • Long-term risks were not reported.

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