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GlycineEvidence & Dosage

Glycine, sleep quality, body temperature and safety.

Evidence at a glance

Total studies
90
With abstract
24
Meta / Systematic / RCT
4
Highly cited
28
Publication years
1970–2026

Glycine in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Glycine

Ranked by influential-citation count and publication year.

  1. The glycinergic inhibitory synapse.

    Cell Mol Life Sci2001Review99 influential citations

    Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the brainstem, and glycinergic synapses have a well-established role in the regulation of locomotor behavior. Research over the last 15 years has…

  2. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.

    Oxid Med Cell Longev2017Review87 influential citations

    Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and…

  3. Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.

    Science2023Study67 influential citations

    Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein-coupled…

  4. Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.

    Elife2022n=4Study62 influential citations

    First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple modes of tissue…

  5. Insulin resistance and glycine metabolism in humans.

    Amino Acids2018Review59 influential citations

    Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration. In prospective studies, hypoglycinemia at baseline predicts the risk of developing type 2…

  6. Glycine receptors: Structure, function, and therapeutic implications.

    Mol Aspects Med2025Review30 influential citations

    Glycine receptors are considered as an integral part of higher brain function in mammals. The main function of glycine receptor is fast inhibitory transmission brought about by glycine neurotransmitter, its full agonist. This receptor is…

  7. Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia.

    Front Psychiatry2020Review24 influential citations

    Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global…

  8. Glycine as a neurotransmitter in the forebrain: a short review.

    J Neural Transm (Vienna)2009Review19 influential citations

    Since the late 1970s glycine has been considered an important inhibitory neurotransmitter in brain stem and medulla. The description of its involvement in the mechanism of action of the potent neurotoxin strychnine pushed further the…

  9. Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases.

    Front Immunol2021Review16 influential citations

    Accumulating evidences support that amino acids direct the fate decision of immune cells. Glycine is a simple structural amino acid acting as an inhibitory neurotransmitter. Besides, glycine receptors as well as glycine transporters are…

  10. Glycine modulators in schizophrenia.

    Curr Opin Investig Drugs2002Review11 influential citations

    N-methyl-D-aspartate (NMDA) receptor dysfunction may play a key role in the pathophysiology of schizophrenia. Recent studies have investigated the ability of NMDA/glycine-site modulators to ameliorate persistent negative and cognitive…

Frequently asked

What dosage was studied?
• Oral, intravenous, dietary, and experimental glycine supplementation (Varies across cited studies; examples include 2 g/day orally, 3 mM, 25 mg/kg, 50-300 mg/kg, 250 ml of 300 mM)
Are there safety considerations for Glycine?
• Large amounts of glycine are toxic to the human body. • Oral glycine is quickly metabolized in the digestive system. • Human liver transplant protocols used 250 ml of 300 mM glycine pre-implantation and 25 ml daily post-op. • The review notes the need for precautions for safe intake and dose.

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