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Insulin Sensitivity NutritionEvidence & Dosage

Nutrition strategies for improved insulin sensitivity: macronutrient timing, fiber, polyphenols, and the evidence base for metabolic health.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
49
Meta / Systematic / RCT
261
Highly cited
50
Publication years
1990–2026

Insulin Sensitivity Nutrition in the context of Methods

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Top studies on Insulin Sensitivity Nutrition

Ranked by influential-citation count and publication year.

  1. Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data.

    BMJ2021n=1,357Meta-Analysis200 influential citations

    Objective To determine the efficacy and safety of low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) for people with type 2 diabetes. Design Systematic review and meta-analysis. Data sources Searches of CENTRAL, Medline,…

  2. Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases.

    Eur J Intern Med2025Systematic Review200 influential citations

    The Triglyceride-glucose index (TyG index) is a comprehensive statistical measure that incorporates fasting triglyceride and fasting glucose levels. Research has demonstrated that it can serve as an effective alternative biomarker for…

  3. Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis.

    Ann Phys Rehabil Med2019n=846Meta-Analysis159 influential citations

    <h4>Background</h4>Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is…

  4. The Effect of the Mediterranean Diet on Metabolic Health: A Systematic Review and Meta-Analysis of Controlled Trials in Adults.

    Nutrients2020n=36,983Meta-Analysis121 influential citations

    The Mediterranean diet (MD) may provide metabolic benefits but no systematic review to date has examined its effect on a multitude of outcomes related to metabolic health. This systematic review with meta-analysis (International…

  5. Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis.

    Nutr Diabetes2020n=567meta108 influential citations

    BACKGROUND: At present, the beneficial effect of the ketogenic diet (KD) on weight loss in obese patients is generally recognized. However, a systematic research on the role of KD in the improvement of glycemic and lipid metabolism of…

  6. The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders: A Systematic Review.

    Nutrients2024n=36Systematic Review98 influential citations

    <h4>Background</h4>Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic…

  7. A Systematic Review of Animal Models of NAFLD Finds High-Fat, High-Fructose Diets Most Closely Resemble Human NAFLD.

    Hepatology2021n=3,920Systematic Review88 influential citations

    Background and Aims Animal models of human disease are a key component of translational hepatology research, yet there is no consensus on which model is optimal for NAFLD. Approach and Results We generated a database of 3,920 rodent models…

  8. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

    Nat Commun2021n=73,089Meta-Analysis82 influential citations

    Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however,…

  9. The Effect of Early Time-Restricted Eating vs Later Time-Restricted Eating on Weight Loss and Metabolic Health.

    J Clin Endocrinol Metab2023n=730Meta-Analysis81 influential citations

    Context It remains controversial whether the choice of the daily eating window early or later in time-restricted eating (TRE) intervention (early or later TRE) has different effects on weight loss and metabolic health. Objective A network…

  10. Vitamins C, E, and β-Carotene and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.

    Adv Nutr2024n=619Meta-Analysis80 influential citations

    A systematic review and meta-analysis was conducted to assess the relationship between the common dietary antioxidants vitamin C, vitamin E, and β-carotene and type 2 diabetes (T2D) and related traits. MEDLINE, Embase, and the Cochrane…

    Finding: Higher dietary vitamin C and vitamin E supplementation were associated with reduced insulin resistance.

Frequently asked

What dosage was studied?
• low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) (<130 g/day or <26% of a 2000 kcal/day diet for LCDs; <10% calories from carbohydrates for VLCDs) • Triglyceride-glucose (TyG) index assessment (not reported) • Structured exercise intervention program
Which population does the evidence apply to?
Most studies investigated: unknown; patient.
Are there safety considerations for Insulin Sensitivity Nutrition?
• No significant or clinically important differences in adverse events at 6 or 12 months. • No significant or clinically important between-group differences in blood lipids at 6 and 12 months. • 12-month quality of life and LDL cholesterol worsened clinically, though not statistically significant. • not reported

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