Ketogenic DietEvidence & Dosage
Ketosis, beta-hydroxybutyrate, exogenous ketones, neurological applications, and the evidence on fat adaptation.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 41
- Meta / Systematic / RCT
- 117
- Highly cited
- 50
- Publication years
- 1979–2026
Ketogenic Diet in the context of Methods
This topic is part of our "Methods" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to MethodsTop studies on Ketogenic Diet
Ranked by influential-citation count and publication year.
The Role of Lifestyle Interventions in PCOS Management: A Systematic Review.
Nutrients2025n=296Systematic Review174 influential citationsPolycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders among reproductive-aged women. It is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Lifestyle changes are suggested as first-line…
The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trials.
Nutr Rev2025n=44Meta-Analysis160 influential citations<h4>Context</h4>Despite the important role of inflammation-related factors on the occurrence of chronic diseases, there is still conflicting evidence about the effects of the ketogenic diet (KD) on these factors.<h4>Objective</h4>In order…
Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE).
J Endocrinol Invest2019Systematic Review123 influential citations<h4>Background</h4>Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in clinical…
Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis.
Nutr Diabetes2020n=567meta108 influential citationsBACKGROUND: At present, the beneficial effect of the ketogenic diet (KD) on weight loss in obese patients is generally recognized. However, a systematic research on the role of KD in the improvement of glycemic and lipid metabolism of…
Ketogenic Diet and Microbiota: Friends or Enemies?
Genes (Basel)2019Review101 influential citationsOver the last years, a growing body of evidence suggests that gut microbial communities play a fundamental role in many aspects of human health and diseases. The gut microbiota is a very dynamic entity influenced by environment and…
Ketogenic diets for drug-resistant epilepsy.
Cochrane Database Syst Rev2018n=778Systematic Review91 influential citations<h4>Background</h4>Ketogenic diets (KDs), being high in fat and low in carbohydrates, have been suggested to reduce seizure frequency in people with epilepsy. At present, such diets are mainly recommended for children who continue to have…
Ketogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails.
Int J Environ Res Public Health2022n=611meta90 influential citationsA ketogenic diet, characterized by low calories with high levels of fat, adequate levels of protein, and low levels of carbohydrates, has beneficial effects on body weight control in overweight patients. In the present study, a…
Ketogenic diet and other dietary treatments for epilepsy.
Cochrane Database Syst Rev2016n=427Systematic Review89 influential citations<h4>Background</h4>The ketogenic diet (KD), being high in fat and low in carbohydrates, has been suggested to reduce seizure frequency. It is currently used mainly for children who continue to have seizures despite treatment with…
Effects of ketogenic diet on cognitive function of patients with Alzheimer's disease: a systematic review and meta-analysis.
J Nutr Health Aging2024n=691Meta-Analysis85 influential citations<h4>Background</h4>Ketogenic diets (KD) have shown remarkable effects in many disease areas. It has been demonstrated in numerous animal experiments that KD is effective in the treatment of Alzheimer's disease (AD). But the clinical effect…
Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials.
Nutrients2023n=480meta75 influential citationsBackground: Dietary patterns play a critical role in diabetes management, while the best dietary pattern for Type 2 diabetes (T2DM) patients is still unclear. The aim of this network meta-analysis was to compare the impacts of various…
Frequently asked
What dosage was studied?
Which population does the evidence apply to?
Are there safety considerations for Ketogenic Diet?
Related articles
Ketogenic Diet - Scientific Evidence and Studies | BAI
The ketogenic diet is based on the idea of putting the body into a state of fat burning. Scientific studies have shown that it can be effective in certain health conditions such as epilepsy or neurodegenerative diseases.
Ketogenic Diet: Effects & Evidence—What Is Actually Supported
Evidence-based overview of the ketogenic diet: which effects are supported in meta-analyses, where the data is limited—and what remains unclear.
More topics in Methods
HRV Biofeedback
Heart rate variability as a stress marker, breath protocols for vagal activation, wearables (Oura, Whoop), and training-load steering.
Light Management
Morning light, blue-light filtering and the circadian rhythm.
Sleep Hygiene
Light management, temperature, consistency, and sleep architecture optimization.
Microbiome Modulation
Pro- and prebiotics, fiber, fermented foods, the gut-brain axis, and evidence on immune and metabolic modulation.
Insulin Sensitivity Nutrition
Nutrition strategies for improved insulin sensitivity: macronutrient timing, fiber, polyphenols, and the evidence base for metabolic health.
Intermittent Fasting
16:8, OMAD, 5:2: metabolic flexibility, insulin sensitivity, autophagy, and the evidence on weight loss.
Cold Exposure
Ice baths, cold showers, cold plunges: mechanisms, brown fat activation, metabolism, mood effects, and safety protocols.
Air Quality
PM2.5, PM10, HEPA filters, indoor vs. outdoor — cognitive and cardiovascular effects.
Alcohol
No safe dose per recent evidence — sleep, hormones, cancer risk.
Blue Light
Screen spectrum suppresses melatonin — filters, glasses, incandescent bulbs.
Breakfast Yes/No
The state of research on breakfast's role — myths and individual variability.
Breathwork
Wim Hof, Box Breathing, Pranayama, and autonomic nervous system
Burnout Prevention
Early warning signs, workload management, recovery, setting boundaries.
Carbohydrates
Glycemic index, starch vs. sugar, individual tolerance.
Carnivore Diet
An all-meat diet — anecdotes vs. missing long-term evidence.
Chronotype
Lark vs. owl — genetically influenced, your optimal daily structure.
Dietary Fats
Saturated vs. unsaturated, omega profiles, avoiding trans fats.
Dietary Protein
Daily requirement, sources, distribution across the day, leucine threshold.
Digital Minimalism
Deliberate tech use, screen time, notification hygiene.
EMF
A contested topic — the evidence, the precautionary principle, the practical side.
Related topics from other worlds
WADA/Doping
The list of banned substances — GH releasers, IGF-1, erythropoietin and more.
Citrulline Malate
NO precursor, pump and endurance studies.
Endurance
Aerobic base, lactate threshold, VO2max, polarized training.
Massage Guns
Theragun and the like — short-term effects, no lasting performance gain.
Progressive Overload
Incremental increases in load — the fundamental rule of training.
Training Intensity
% 1RM, RIR/RPE — the control variable for adaptation.