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Microbiome ModulationEvidence & Dosage

Pro- and prebiotics, fiber, fermented foods, the gut-brain axis, and evidence on immune and metabolic modulation.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
41
Meta / Systematic / RCT
94
Highly cited
14
Publication years
2001–2026

Microbiome Modulation in the context of Methods

This topic is part of our "Methods" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Microbiome Modulation

Ranked by influential-citation count and publication year.

  1. Gut microbiome changes and cancer immunotherapy outcomes associated with dietary interventions: a systematic review of preclinical and clinical evidence.

    J Transl Med2025n=293Systematic Review41 influential citations

    <h4>Introduction</h4>Cancer patient's survival has gradually improved due to immune checkpoint inhibitors (ICIs). Several studies showed a possible association between the intestinal microbiome and ICI efficacy. Strategies for modifying…

  2. Clinical efficacy of fecal microbiota transplantation in alleviating depressive symptoms: a meta-analysis of randomized trials.

    Front Psychiatry2025n=681Systematic Review36 influential citations

    <h4>Background</h4>Depressive symptoms are common in neuropsychiatric disorders, significantly affecting quality of life and posing challenges to treatment. While pharmacological and psychological therapies remain standard, many patients…

  3. Metabolomics in Multiple Sclerosis: Advances, Challenges, and Clinical Perspectives-A Systematic Review.

    Int J Mol Sci2025n=29Systematic Review35 influential citations

    Multiple sclerosis (MS) is a chronic, immune-mediated neurodegenerative disorder marked by inflammation, demyelination, and neuronal loss within the central nervous system. Despite advances in diagnostics, current tools remain…

  4. Microbiome Modulation for the Treatment of Solid Neoplasms.

    2025n=3027 influential citations

    The interplay between the human gut microbiome and the immune system has sparked growing interest in microbiome modulation as a therapeutic strategy in oncology. Preclinical studies have identified specific bacterial species linked to…

  5. Rational bioengineering of polysaccharide in designing of microbiome modulation.

    20263 influential citations

    Targeted modulation of the gut microbiome offers significant promise for preventing and treating diverse diseases; yet, enhancing the efficacy of these interventions remains challenging. Polysaccharides have emerged as potent microbiome…

  6. Microbiome modulation of tumorigenesis and immune responses.

    20262 influential citations

    The microbiome has emerged as a critical, context-dependent regulator of tumorigenesis and anticancer immunity, capable of either promoting cancer progression or protecting against malignancy. This dual role is mediated by multiple…

  7. Microbiota and Alzheimer's disease: mechanistic insights from a multi-organ perspective.

    Translational neurodegeneration20262 influential citations

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder driven by multifactorial mechanisms. Increasing evidence suggests that dysbiosis, a term denoting an imbalance in the composition of the microbiota, may play a pivotal…

  8. The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis.

    Gastroenterology2026n=174Systematic Review2 influential citations

    <h4>Background & aims</h4>Few studies describe gut microbiome signatures in treatment-naïve new-onset inflammatory bowel disease (IBD). We present a novel secondary bioinformatic reanalysis of sequence outputs mapped to the latest…

  9. Butyrate-Producing Bacteria as a Keystone Species of the Gut Microbiome: A Systemic Review of Dietary Impact on Gut-Brain and Host Health.

    Int J Mol Sci2026Systematic Review2 influential citations

    The human gut microbiome is a complex ecosystem integral to host health, with butyrate-producing bacteria (BPB) playing a critical role in maintaining intestinal homeostasis. This scoping review explores the composition, function, and…

  10. Evaluation of bacteriophages as a signature of microbiome health: a systematic review and meta-analysis.

    Lancet Microbe2025n=74Meta-Analysis2 influential citations

    <h4>Background</h4>Parasites are foundational to ecosystem health both as indicator species of community productivity and as drivers of diversity. In bacterial communities, bacteriophage viruses can have such roles as they track and…

Frequently asked

What dosage was studied?
• Not applicable (review of microbiome-related mechanisms and therapeutic modulation strategies) • Gut microbiome modulation, including diet, prebiotics, probiotics, postbiotics, selective antibiotics, and fecal microbiota transplantation (not reported) • Restore diet recapitulating key characteristics of non-industrialized dietary patterns, with or without Limosilactobacillus reuteri PB-W1 (Not reported for diet; L. reuteri PB-W1 dose not reported in abstract)
Which population does the evidence apply to?
Most studies investigated: animal.
Are there safety considerations for Microbiome Modulation?
• Not reported in the abstract. • Irinotecan can cause diarrhoea via bacterial β-glucuronidase activity. • Checkpoint inhibitors may be associated with immune-related colitis. • Broad-spectrum antibiotics may reduce checkpoint inhibitor effectiveness.

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