Epigenetic ClocksEvidence & Dosage
Horvath, GrimAge, PhenoAge — what they measure and what they don't.
Evidence at a glance
- Total studies
- 823
- With abstract
- 45
- Meta / Systematic / RCT
- 3
- Highly cited
- 4
- Publication years
- 2002–2027
Epigenetic Clocks in the context of Longevity
This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to LongevityTop studies on Epigenetic Clocks
Ranked by influential-citation count and publication year.
Epigenetic ageing clocks: statistical methods and emerging computational challenges.
Nature reviews. Genetics2025200 influential citationsOver the past decade, epigenetic clocks have emerged as powerful machine learning tools, not only to estimate chronological and biological age but also to assess the efficacy of anti-ageing, cellular rejuvenation and disease-preventive…
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations.
Ageing Res Rev2024n=299Meta-Analysis94 influential citationsEpigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on…
Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
GeroScience202476 influential citationsDNA methylation (DNAm) clocks hold promise for measuring biological age, useful for guiding clinical interventions and forensic identification. This study compared the commonly used DNAm clocks, using DNA methylation and SNP data generated…
Multi-omic underpinnings of heterogeneous aging across multiple organ systems.
Cell genomics202520 influential citationsAging is the main determinant of chronic diseases and mortality, yet organ-specific aging trajectories vary, and the molecular basis underlying this heterogeneity remains unclear. To elucidate this, we integrated genomic, epigenomic,…
The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases.
Biochimica et biophysica acta. Molecular basis of disease20264 influential citationsBiological aging is a complex, multifaceted process characterized by the progressive erosion of cellular homeostasis, driven by intersecting pathways of inflammaging, immune senescence, mitochondrial dysfunction, and genomic instability.…
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.
Nature communications2025n=18,8594 influential citationsEpigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a…
Measuring biological age: Insights from omics studies.
Ageing research reviews20263 influential citationsBiological ageing is a systemic, multifactorial process driven by progressive molecular and cellular alterations whose complexity necessitates systems-level approaches. Advances in high-throughput omics technologies now allow simultaneous…
Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial.
Nature medicine2026n=9583 influential citationsLarge-scale randomized trials have found that multivitamin-multimineral (MVM) supplements and cocoa flavanols may benefit several age-related chronic conditions among older adults, but it remains unclear whether these two supplements…
Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.
Biopsychosocial science and medicine2025n=1,2053 influential citations<h4>Objective</h4>To quantify the association between neighborhood opportunity and biological aging as measured by epigenetic clocks.<h4>Methods</h4>This cross-sectional study pooled data from 1205 participants in the Midlife in the United…
Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity.
BMC medicine2025n=3,3123 influential citations<h4>Background</h4>Previous studies reported mixed findings in the relationship between body mass index (BMI) and epigenetic age acceleration (EAA), while none considered long-term trajectory of BMI and individuals' genetic background.…
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