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Longevity

GlucosamineEvidence & Dosage

Joints, UK Biobank mortality study, sulfate vs HCl forms.

Studies last updated

Evidence at a glance

Total studies
788
With abstract
50
Meta / Systematic / RCT
103
Highly cited
50
Publication years
1980–2026

Glucosamine in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Glucosamine

Ranked by influential-citation count and publication year.

  1. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.

    Osteoarthritis Cartilage2008n=23Systematic Review200 influential citations

    <h4>Purpose</h4>To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied…

  2. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

    JAMA2000n=15Meta-Analysis176 influential citations

    <h4>Context</h4>Glucosamine and chondroitin preparations are widely touted in the lay press as remedies for osteoarthritis (OA), but uncertainty about their efficacy exists among the medical community.<h4>Objective</h4>To evaluate benefit…

    Finding: This meta-analysis found moderate to large pooled effects for glucosamine and chondroitin on osteoarthritis symptoms.

  3. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis.

    BMJ2010n=380Meta-Analysis132 influential citations

    <h4>Objective</h4>To determine the effect of glucosamine, chondroitin, or the two in combination on joint pain and on radiological progression of disease in osteoarthritis of the hip or knee. Design Network meta-analysis. Direct…

  4. Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

    JAMA2018n=22,037Meta-Analysis122 influential citations

    <h4>Importance</h4>Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in unclear recommendations for long-term disease…

  5. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

    Br J Sports Med2018n=69Meta-Analysis111 influential citations

    Objective To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis. Design An intervention systematic review with random effects meta-analysis and meta-regression. Data sources MEDLINE, EMBASE,…

  6. Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee.

    BMC Musculoskelet Disord2019n=34Systematic Review105 influential citations

    <h4>Background</h4>There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of…

  7. Glucosamine therapy for treating osteoarthritis.

    Cochrane Database Syst Rev2005n=257Meta-Analysis99 influential citations

    <h4>Background</h4>Osteoarthritis (OA) is the most common form of arthritis, and it is often associated with significant disability and an impaired quality of life.<h4>Objectives</h4>To review all randomized controlled trials (RCTs)…

  8. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

    Arch Intern Med2003Meta-Analysis78 influential citations

    <h4>Objective</h4>To assess the structural and symptomatic efficacy of oral glucosamine sulfate and chondroitin sulfate in knee osteoarthritis through independent meta-analyses of their effects on joint space narrowing, Lequesne Index,…

  9. Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis.

    Arch Orthop Trauma Surg2023n=379Meta-Analysis74 influential citations

    <h4>Aims</h4>Though glucosamine and chondroitin have become common practices for treating knee osteoarthritis, the clinical value of these two drugs in combination are still questionable. To evaluate the efficacy and safety of the…

    Finding: The meta-analysis found no significant differences in VAS score for any of the comparisons.

  10. Chondroitin for osteoarthritis.

    Cochrane Database Syst Rev2015n=4,962Meta-Analysis67 influential citations

    <h4>Background</h4>Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin.…

Frequently asked

What dosage was studied?
• OARSI evidence-based, expert consensus recommendations for management of hip and knee osteoarthritis (Not reported) • glucosamine or chondroitin • Glucosamine, chondroitin, or glucosamine + chondroitin (Not reported)
Are there safety considerations for Glucosamine?
• Not reported • Not reported in the abstract. • Not reported in abstract. • Not reported in the abstract

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