Back to Longevity
Longevity

CollagenEvidence & Dosage

Skin, joints, tendons — evidence favors hydrolysate plus vitamin C.

Evidence at a glance

Total studies
1,000
With abstract
38
Meta / Systematic / RCT
0
Highly cited
4
Publication years
1950–2026

Collagen in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Longevity

Top studies on Collagen

Ranked by influential-citation count and publication year.

  1. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.

    American journal of ophthalmology2003n=22200 influential citations

    <h4>Purpose</h4>In animal eyes, a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment. The aim of the present study was to evaluate the…

  2. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

    Molecular and cellular biology2009200 influential citations

    Adipocytes are embedded in a unique extracellular matrix whose main function is to provide mechanical support, in addition to participating in a variety of signaling events. During adipose tissue expansion, the extracellular matrix…

  3. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

    Proceedings of the National Academy of Sciences of the United States of America2000132 influential citations

    The therapeutic potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis, was explored in murine collagen-induced arthritis (CIA). CIA was elicited by immunizing DBA/1 mice with type II collagen (CII) in complete…

  4. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

    Proceedings of the National Academy of Sciences1986

    Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn mice, causes formation of granulation tissue (induction of angiogenesis and activation of fibroblasts to produce collagen) at the site of injection.…

  5. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

    Journal of Biological Chemistry1986

    We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). We find that TGFbeta increases the expression of the major extracellular matrix proteins, fibronectin and collagen.…

  6. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

    Cell1982

    The differentiated phenotype of rabbit articular chondrocytes consists primarily of type II collagen and cartilage-specific proteoglycan. During serial monolayer culture this phenotype is lost and replaced by a complex collagen phenotype…

  7. Electrospinning of Collagen Nanofibers

    Biomacromolecules2002

    Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers onto a target substrate. This electrostatic processing strategy can be used to fabricate fibrous polymer mats composed of…

  8. The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering

    Biomaterials2009

    In the literature there are conflicting reports on the optimal scaffold mean pore size required for successful bone tissue engineering. This study set out to investigate the effect of mean pore size, in a series of…

  9. Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility

    The Journal of Cell Biology1997

    Decorin is a member of the expanding group of widely distributed small leucine-rich proteoglycans that are expected to play important functions in tissue assembly. We report that mice harboring a targeted disruption of the decorin gene are…

  10. Collagen density promotes mammary tumor initiation and progression

    BMC Medicine2008

    <h4>Background</h4>Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the strong clinical correlation, breast density has not been causally linked to tumorigenesis, largely…

Related articles

Knowledge

Vitamin C for Regeneration - How Effective is it According to Scientific Studies?

Vitamin C may positively influence regeneration according to some studies. It is believed that it can reduce oxidative stress and promote collagen production. However, the current results are still limited.

More topics in Longevity

Zone 2 Training

Low-intensity cardio — mitochondrial biogenesis, a longevity foundation.

Rapamycin

mTOR inhibition, longevity studies, off‑label dosing, and safety.

AMPK Activators

Berberine, alpha‑lipoic acid, energetic stress, and glucose modulation.

ApoB

A better cardiovascular risk metric than LDL-C — modern lipidology.

Autophagy

Cellular self-clearance — fasting, exercise, spermidine as triggers.

Berberin

Glucose, lipids, AMPK and GI tolerability data

Biological Age

GrimAge, PhenoAge, DunedinPACE — what epigenetic clocks measure.

Caloric Restriction

CR mimetics, lifespan research, and NHP studies.

Cancer Screening

Recommendations, overdiagnosis, Galleri tests, whole-body MRI (a critical look).

Cellular Senescence

"Zombie cells," SASP, senolytic approaches.

Dementia Prevention

Lifestyle factors: exercise, sleep, hearing health, vascular health.

DEXA Bone Density

DEXA scan for bone + body composition — the trend matters more than a single value.

Epigenetic Clocks

Horvath, GrimAge, PhenoAge — what they measure and what they don't.

Epigenetics

DNA methylation, histone modifications, environmental influences on gene expression.

Exosomes

Cell-to-cell communication, regenerative applications, an early research field.

Genetic Tests

Variants, pharmacogenomics, limitations — methylation, MTHFR myths.

Glucosamine

Joints, UK Biobank mortality study, sulfate vs HCl forms.

Glycine

Methylation, collagen synthesis, lifespan signals in animal models.

Grip Strength

A strong mortality predictor — easy to measure, trainable.

Hallmarks of Aging

Genomic instability, telomere shortening, epigenetic alterations, and more.

Related topics from other worlds

Mental

Caffeine & Anxiety

Adenosine antagonism, individual sensitivity, cut-off strategies.

Mental

EMDR / Trauma Therapy

PTSD, eye movements, and study effectiveness.

Mental

Lavender

Silexan studies, oral and olfactory — anxiolysis with a good safety profile.

Mental

Polyvagal Theory

Popular but scientifically contested — strengths and weaknesses.

Mental

Somatic Therapy

Body-oriented trauma work — Somatic Experiencing and others.

Peptides

Administration Routes

Subcutaneous, intramuscular, nasal, oral, topical — bioavailability and safety.