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Caffeine & AnxietyEvidence & Dosage

Adenosine antagonism, individual sensitivity, cut-off strategies.

Evidence at a glance

Total studies
1,000
With abstract
44
Meta / Systematic / RCT
7
Highly cited
12
Publication years
1941–2026

Caffeine & Anxiety in the context of Mental

This topic is part of our "Mental" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Caffeine & Anxiety

Ranked by influential-citation count and publication year.

  1. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans.

    Journal of clinical pharmacology199797 influential citations

    Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of caffeine in a randomized, double-blind, single-dose crossover study. Caffeine kinetics were nonlinear, with clearance significantly reduced and elimination…

  2. Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2003n=9468 influential citations

    The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to…

  3. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008n=10253 influential citations

    Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing adenosine at A(1) and A(2A) receptors, and perhaps through interactions with other transmitter systems. Adenosine receptors are colocalized and…

  4. Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology201049 influential citations

    Caffeine, a widely consumed adenosine A(1) and A(2A) receptor antagonist, is valued as a psychostimulant, but it is also anxiogenic. An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been…

  5. Music improves sleep quality in older adults.

    Journal of advanced nursing200548 influential citations

    <h4>Aim</h4>The aim of this paper is to report an investigation of the effects of soft music on sleep quality in older community-dwelling men and women in Taiwan.<h4>Background</h4>Sleep is a complex rhythmic state that may be affected by…

  6. Sleep disturbances in prepubertal children with attention deficit hyperactivity disorder: a home polysomnography study.

    Sleep2009n=1540 influential citations

    <h4>Study objective</h4>To examine sleep architecture and reported sleep problems in children with ADHD and normal controls, while considering the roles of pertinent moderating factors.<h4>Design</h4>Overnight sleep recordings were…

  7. Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type.

    Psychopharmacology199739 influential citations

    Psychopharmacological studies using caffeinated beverages or caffeine have rarely considered temporal effects on psychological and physiological function or the specific contribution of caffeine, hot water, or beverage type to the observed…

  8. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together.

    Psychopharmacology (Berl)2008n=48RCT35 influential citations

    <h4>Rationale</h4>Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is…

  9. Effects of Subanesthetic Oromucosal Dexmedetomidine on Sleep in Humans: A Randomized, Controlled Pharmacokinetics-Pharmacodynamics Study.

    Anesthesiology2025n=25rct31 influential citations

    BACKGROUND: The locus coeruleus noradrenergic system may provide a potential new target for pharmacologic insomnia treatment, particularly in patients suffering from elevated distress. The selective &#x3b1; 2 -noradrenergic agonist…

  10. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.

    J Physiol Anthropol2012n=14RCT27 influential citations

    <h4>Background</h4>L-theanine, an amino acid contained in green tea leaves, is known to block the binding of L-glutamic acid to glutamate receptors in the brain, and has been considered to cause anti-stress effects by inhibiting cortical…

Frequently asked

Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Caffeine & Anxiety?
• Caffeine increased jitteriness and blood pressure. • Theanine antagonized caffeine's blood-pressure effect. • No adverse events were reported in the abstract. • No orthostatic dysregulation was observed overall.

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