SHBGEvidence & Dosage

Top studies on SHBG

Ranked by influential-citation count and publication year.

1. 01

   New Insights in the Diagnostic Potential of Sex Hormone-Binding Globulin (SHBG)—Clinical Approach

   Biomedicines·202546 influential citations

   SHBG is a glycoprotein that not only controls serum sex hormone levels but is also strongly correlated with metabolic syndrome, cardiovascular risk, thyroid function, gynecological conditions, and even the process of carcinogenesis.…

2. 02

   The Cut-Off Value for the Triglyceride–Glucose Index (TyG) Discriminating Insulin Resistance Based on the SHBG Level and HOMA-IR Values in Women with Polycystic Ovary Syndrome

   Life·202541 influential citations

   The triglyceride-glucose (TyG) index was recently suggested as a surrogate marker of liver steatosis and insulin resistance. However, the TyG index cut-off value may be affected by age, sex, and race. Therefore, this study aimed to…

3. 03

   Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance

   BMC Endocrine Disorders·202440 influential citations

   <h4>Objective</h4>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present…

4. 04

   Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and Risk of Incident Diabetes: The Study of Women’s Health Across the Nation (SWAN)

   Diabetes Care·2024·n=2,95236 influential citations

   <h4>Objective</h4>To investigate the associations of longitudinal changes in sex hormone binding globulin (SHBG) and testosterone (T) over the menopause transition with the risk of diabetes.<h4>Research design and methods</h4>We followed…

5. 05

   SHBG Gene Polymorphisms and Their Influence on Serum SHBG, Total and Free Testosterone Concentrations in Men

   The Journal of Clinical Endocrinology &amp; Metabolism·2024·n=31432 influential citations

   <h4>Context</h4>Genetic variation in SHBG structure may affect estimates of sex steroid exposure by altering the affinity of the protein for its ligand. Consequently, free hormone calculations assuming constant binding affinity may, for…

6. 06

   Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities.

   Clinical endocrinology·2001·n=5026 influential citations

   <h4>Background</h4>Hypopituitarism in adults is associated with increased vascular mortality, which has been attributed to GH deficiency.<h4>Objective</h4>To compare the lipid profile and coronary risk predicted by the Framingham Heart…

7. 07

   Relations of Insulin Resistance, Body Weight, Vitamin D Deficiency, SHBG and Androgen Levels in PCOS Patients

   Biomedicines·2025·n=19522 influential citations

   <b>Background:</b> The most common female endocrinopathy is polycystic ovary syndrome (PCOS), affecting 10-20% of women of reproductive age. It is associated with a wide range of hormonal and biochemical abnormalities and long-term…

8. 08

   Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-aged to Older Men

   The Journal of Clinical Endocrinology &amp; Metabolism·2024·n=97322 influential citations

   <h4>Context</h4>As men age, circulating testosterone (T) decreases, circulating SHBG increases, and the risk of fracture increases. It is unclear if circulating T, independently of comorbidities, is associated with fracture risk in…

9. 09

   Hyperglycemia Inhibits Hepatic SHBG Synthesis Through the NGBR‐AMPK‐HNF4 Pathway in Rats with Polycystic Ovary Syndrome Induced by Letrozole in Combination with a High‐Fat Diet

   Molecular Nutrition &amp; Food Research·202416 influential citations

   <h4>Scope</h4>Polycystic ovary syndrome (PCOS) is closely related to non-alcoholic fatty liver disease (NAFLD), and sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver. Hepatic lipogenesis inhibits hepatic SHBG…

10. 10

    The Role of SHBG as a Marker in Male Patients with Metabolic-Associated Fatty Liver Disease: Insights into Metabolic and Hormonal Status

    Journal of Clinical Medicine·202414 influential citations

    <b>Background</b>: Metabolic-associated fatty liver disease (MAFLD) is a spectrum of liver diseases linked to insulin resistance (IR), type 2 diabetes, and metabolic disorders. IR accelerates fat accumulation in the liver, worsening MAFLD.…