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Longevity

OsteoporosisEvidence & Dosage

Preserving bone mass — loading, vitamin D, K2, calcium, protein.

Evidence at a glance

Total studies
1,000
With abstract
44
Meta / Systematic / RCT
2
Highly cited
13
Publication years
1989–2026

Osteoporosis in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Osteoporosis

Ranked by influential-citation count and publication year.

  1. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

    The New England journal of medicine2001200 influential citations

    <h4>Background</h4>Once-daily injections of parathyroid hormone or its amino-terminal fragments increase bone formation and bone mass without causing hypercalcemia, but their effects on fractures are unknown.<h4>Methods</h4>We randomly…

  2. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA1994200 influential citations

    The criteria required for an effective screening strategy for osteoporosis are largely met in Caucasian women. The disease is common and readily diagnosed by the measurement of bone mineral with single- or dual-energy absorptiometry. Such…

  3. Long-term and sequential treatment for osteoporosis.

    Nature reviews. Endocrinology2023200 influential citations

    Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength, leading to a progressively increased risk of fragility fractures. The global prevalence of osteoporosis is increasing in the ageing population.…

  4. The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review.

    Frontiers in immunology2023200 influential citations

    The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology. In this field, cytokines that are among osteoblasts and…

  5. Insights and implications of sexual dimorphism in osteoporosis.

    Bone research2024200 influential citations

    Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures worldwide. Accumulating evidence has revealed that sexual…

  6. Treatment of postmenopausal osteoporosis.

    Lancet (London, England)2002128 influential citations

    The aim of treatment of postmenopausal osteoporosis is to reduce the frequency of vertebral and non-vertebral fractures (especially at the hip), which are responsible for morbidity associated with the disease. Results of large placebo…

  7. The association of osteoprotegerin and RANKL with osteoporosis: a systematic review with meta-analysis.

    J Orthop Surg Res2023n=154Meta-Analysis45 influential citations

    Objectives The OPG/RANKL signal pathway was important regulation mechanism of bone remodeling cycle, but the effect of osteoprotegerin (OPG) and RANKL in osteoporosis was uncertain. We did a systematic review with meta-analysis to assess…

    Finding: In this systematic review and meta-analysis, serum OPG showed no significant difference between the osteoporosis and control groups.

  8. The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis.

    J Ethnopharmacol2011n=3225 influential citations

    <h4>Aim of the study</h4>Postmenopausal osteoporosis is mainly treated with estrogen replacement therapy (ERT). However, ERT causes side effects, mainly breast cancer, uterine cancer and thromboembolic problems. Labisia pumila var. arata…

  9. Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility.

    Alternative medicine review : a journal of clinical therapeutic2007D21 influential citations

    Bone health, characterized by its mass, density, and micro-architectural qualities, is maintained by a balanced system of remodeling. The lack of these qualities, caused by an uncoupling of the remodeling process, leads to bone fragility…

  10. Osteoporosis prevention and management: nonpharmacologic and lifestyle options.

    Clinical obstetrics and gynecology2013D20 influential citations

    The purpose of this review is to evaluate current evidence regarding the use of dietary and exercise interventions to prevent fractures in postmenopausal women with osteoporosis. The key lifestyle modifications that can decrease risk of…

Frequently asked

Which population does the evidence apply to?
Most studies investigated: unknown; animal.

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