Back to Longevity
Longevity

Dementia PreventionEvidence & Dosage

Lifestyle factors: exercise, sleep, hearing health, vascular health.

Evidence at a glance

Total studies
1,000
With abstract
43
Meta / Systematic / RCT
5
Highly cited
28
Publication years
1968–2026

Dementia Prevention in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Longevity

Top studies on Dementia Prevention

Ranked by influential-citation count and publication year.

  1. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.

    Lancet (London, England)2015n=1,260200 influential citations

    <h4>Background</h4>Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies. In the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability…

  2. An active and socially integrated lifestyle in late life might protect against dementia.

    The Lancet. Neurology2004200 influential citations

    The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic. This review systematically analyses the published…

  3. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.

    Archives of neurology2005n=1,449200 influential citations

    <h4>Background</h4>Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development…

  4. Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons.

    The New England journal of medicine2023n=1,929200 influential citations

    <h4>Background</h4>Findings from observational studies suggest that dietary patterns may offer protective benefits against cognitive decline, but data from clinical trials are limited. The Mediterranean-DASH Intervention for…

  5. Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals.

    JAMA neurology2020n=4,486159 influential citations

    <h4>Importance</h4>The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an ongoing prevention trial in clinically normal older individuals with evidence of elevated brain amyloid. The large number of participants…

  6. Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial.

    Alzheimer's &amp; dementia : the journal of the Alzheimer's Association2024n=531143 influential citations

    <h4>Introduction</h4>We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).<h4>Methods</h4>Participants aged 65-85 years with MCI were…

  7. Association of Daily Step Count and Intensity With Incident Dementia in 78&#x202f;430 Adults Living in the UK.

    JAMA neurology2022n=430135 influential citations

    Importance Step-based recommendations may be appropriate for dementia-prevention guidelines. However, the association of step count and intensity with dementia incidence is unknown. Objective To examine the dose-response association…

  8. Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline.

    European geriatric medicine202399 influential citations

    Background Physical activity and exercise have been suggested as effective interventions for the prevention and management of mild cognitive impairment (MCI) and dementia, but there are no international guidelines. Objectives To create a…

  9. Fruit and vegetable juices and Alzheimer's disease: the Kame Project.

    The American journal of medicine200696 influential citations

    <h4>Background</h4>Growing evidence suggests that oxidative damage caused by the beta-amyloid peptide in the pathogenesis of Alzheimer's disease may be hydrogen peroxide mediated. Many polyphenols, the most abundant dietary antioxidants,…

  10. Advances in the prevention of Alzheimer's disease and dementia.

    Journal of internal medicine2014n=30,00084 influential citations

    <h4>Background</h4>Definitions and diagnostic criteria for all medical conditions are regularly subjected to reviews and revisions as knowledge advances. In the field of Alzheimer's disease (AD) research, it has taken almost three decades…

Frequently asked

What dosage was studied?
• multidomain intervention (diet, exercise, cognitive training, vascular risk monitoring)
Are there safety considerations for Dementia Prevention?
• Adverse events occurred in 46 (7%) participants in the intervention group compared with six (1%) participants in the control group; the most common adverse event was musculoskeletal pain (32 [5%] individuals for intervention vs no individuals for control).

More topics in Longevity

Zone 2 Training

Low-intensity cardio — mitochondrial biogenesis, a longevity foundation.

Rapamycin

mTOR inhibition, longevity studies, off‑label dosing, and safety.

AMPK Activators

Berberine, alpha‑lipoic acid, energetic stress, and glucose modulation.

ApoB

A better cardiovascular risk metric than LDL-C — modern lipidology.

Autophagy

Cellular self-clearance — fasting, exercise, spermidine as triggers.

Berberin

Glucose, lipids, AMPK and GI tolerability data

Biological Age

GrimAge, PhenoAge, DunedinPACE — what epigenetic clocks measure.

Caloric Restriction

CR mimetics, lifespan research, and NHP studies.

Cancer Screening

Recommendations, overdiagnosis, Galleri tests, whole-body MRI (a critical look).

Cellular Senescence

"Zombie cells," SASP, senolytic approaches.

Collagen

Skin, joints, tendons — evidence favors hydrolysate plus vitamin C.

DEXA Bone Density

DEXA scan for bone + body composition — the trend matters more than a single value.

Epigenetic Clocks

Horvath, GrimAge, PhenoAge — what they measure and what they don't.

Epigenetics

DNA methylation, histone modifications, environmental influences on gene expression.

Exosomes

Cell-to-cell communication, regenerative applications, an early research field.

Genetic Tests

Variants, pharmacogenomics, limitations — methylation, MTHFR myths.

Glucosamine

Joints, UK Biobank mortality study, sulfate vs HCl forms.

Glycine

Methylation, collagen synthesis, lifespan signals in animal models.

Grip Strength

A strong mortality predictor — easy to measure, trainable.

Hallmarks of Aging

Genomic instability, telomere shortening, epigenetic alterations, and more.

Related topics from other worlds

Recovery

Massage Therapy

Sports massage, lactate clearance, and recovery outcomes.

Recovery

Sauna for Recovery

Heat Shock, Mitochondrial Repair, and Post‑Workout Application.

Recovery

Yoga

Mobility, breathing, nervous-system regulation, the debate over performance effects.

Sleep

Bedroom Darkness

Blackout curtains, sleep mask — melatonin and sleep depth.

Sleep

CBT-I

Cognitive behavioral therapy for insomnia — first-line therapy per the guidelines.

Sleep

Glycine (Sleep)

3g before bed — lowers core body temperature, modulates deep sleep.