EpigeneticsEvidence & Dosage
DNA methylation, histone modifications, environmental influences on gene expression.
Evidence at a glance
- Total studies
- 818
- With abstract
- 42
- Meta / Systematic / RCT
- 0
- Highly cited
- 4
- Publication years
- 1998–2026
Epigenetics in the context of Longevity
This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to LongevityTop studies on Epigenetics
Ranked by influential-citation count and publication year.
The role of DNA methylation in mammalian epigenetics.
Science (New York, N.Y.)2001200 influential citationsGenes constitute only a small proportion of the total mammalian genome, and the precise control of their expression in the presence of an overwhelming background of noncoding DNA presents a substantial problem for their regulation.…
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.
Genes & development2008100 influential citationsThe enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However,…
Epigenetic reprogramming in mammalian development.
Science (New York, N.Y.)200184 influential citationsDNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are…
Epigenomic analysis of multilineage differentiation of human embryonic stem cells.
Cell2013n=63,95627 influential citationsEpigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To investigate epigenetic regulation of embryonic development, we differentiated human…
Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth
Epigenetics20261 influential citationsBirthweight is heritable and strongly associated with epigenetic differences at birth. It is unclear whether a genetic birthweight score is associated with DNA methylation (DNAm) and, if so, whether through direct genetic effects (i.e.…
Epigenetics and non-coding RNAs in host–endosymbiont interactions: insights from Wolbachia and beyond
Current Opinion in Insect Science20261 influential citationsSymbioses are widespread in nature and are among major evolutionary forces. Insects have recurrently established intracellular symbioses with bacteria, balancing between immune responses and homeostasis. The processes involved in…
Epigenetic and polygenic contributions to body mass index: a validation study of predictive models
Clinical Epigenetics2026n=6241 influential citationsBody mass index (BMI) has a notable genetic component, yet the majority of genetic variants remain elusive. Their identification may be hindered as weight also stems from exogenous factors and may be shaped by lifestyle influences. Since…
Cytokine epigenetics network for gastric cancer progression and chemoresistance
Pharmacological Research20261 influential citationsGastric cancer (GC) is a leading cause of cancer mortality due to late diagnosis, metastasis, and therapy resistance. Epigenetic modifications rewire the cytokine network, facilitating the development, progression, and chemoresistance of…
Epigenetics of sarcopenia: Insights into mechanisms and interventions for healthy muscle aging
Biomedicine & Pharmacotherapy20261 influential citationsAging frequently correlates with the progressive decline in skeletal muscle mass and function, a condition termed sarcopenia. Epigenetic modifications, including DNA methylation, histone alterations, and microRNA regulation, critically…
Alterations in GABAergic Interneurons, Neuroinflammation, and Epigenetics: Potential Targets for Therapeutic Strategies in Schizophrenia.
Current neuropharmacology2026ESchizophrenia (SZ) is a long-term psychiatric condition that affects cognition, thought processing, emotional regulation, and behavior. Epigenetic modifications during pregnancy or early postnatal development increase vulnerability to SZ…
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