EpigenetikStudienlage & Dosis

Top-Studien zu Epigenetik

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   The role of DNA methylation in mammalian epigenetics.

   Science (New York, N.Y.)·2001200 einflussreiche Zitationen

   Genes constitute only a small proportion of the total mammalian genome, and the precise control of their expression in the presence of an overwhelming background of noncoding DNA presents a substantial problem for their regulation.…

2. 02

   Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

   Genes & development·2008100 einflussreiche Zitationen

   The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However,…

3. 03

   Epigenetic reprogramming in mammalian development.

   Science (New York, N.Y.)·200184 einflussreiche Zitationen

   DNA methylation is a major epigenetic modification of the genome that regulates crucial aspects of its function. Genomic methylation patterns in somatic differentiated cells are generally stable and heritable. However, in mammals there are…

4. 04

   Epigenomic analysis of multilineage differentiation of human embryonic stem cells.

   Cell·2013·n=63.95627 einflussreiche Zitationen

   Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To investigate epigenetic regulation of embryonic development, we differentiated human…

5. 05

   Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth

   Epigenetics·20261 einflussreiche Zitationen

   Birthweight is heritable and strongly associated with epigenetic differences at birth. It is unclear whether a genetic birthweight score is associated with DNA methylation (DNAm) and, if so, whether through direct genetic effects (i.e.…

6. 06

   Epigenetics and non-coding RNAs in host–endosymbiont interactions: insights from Wolbachia and beyond

   Current Opinion in Insect Science·20261 einflussreiche Zitationen

   Symbioses are widespread in nature and are among major evolutionary forces. Insects have recurrently established intracellular symbioses with bacteria, balancing between immune responses and homeostasis. The processes involved in…

7. 07

   Epigenetic and polygenic contributions to body mass index: a validation study of predictive models

   Clinical Epigenetics·2026·n=6241 einflussreiche Zitationen

   Body mass index (BMI) has a notable genetic component, yet the majority of genetic variants remain elusive. Their identification may be hindered as weight also stems from exogenous factors and may be shaped by lifestyle influences. Since…

8. 08

   Cytokine epigenetics network for gastric cancer progression and chemoresistance

   Pharmacological Research·20261 einflussreiche Zitationen

   Gastric cancer (GC) is a leading cause of cancer mortality due to late diagnosis, metastasis, and therapy resistance. Epigenetic modifications rewire the cytokine network, facilitating the development, progression, and chemoresistance of…

9. 09

   Epigenetics of sarcopenia: Insights into mechanisms and interventions for healthy muscle aging

   Biomedicine & Pharmacotherapy·20261 einflussreiche Zitationen

   Aging frequently correlates with the progressive decline in skeletal muscle mass and function, a condition termed sarcopenia. Epigenetic modifications, including DNA methylation, histone alterations, and microRNA regulation, critically…

10. 10

    Alterations in GABAergic Interneurons, Neuroinflammation, and Epigenetics: Potential Targets for Therapeutic Strategies in Schizophrenia.

    Current neuropharmacology·2026E

    Schizophrenia (SZ) is a long-term psychiatric condition that affects cognition, thought processing, emotional regulation, and behavior. Epigenetic modifications during pregnancy or early postnatal development increase vulnerability to SZ…