Longevity

Epigenetische UhrenStudienlage & Dosis

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Studienlage in Zahlen

Studien gesamt: 823
Mit Abstract: 45
Meta / Systematic / RCT: 3
Häufig zitiert: 4
Erscheinungsjahre: 2002–2027

Epigenetische Uhren im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu Epigenetische Uhren

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Epigenetic ageing clocks: statistical methods and emerging computational challenges.
Nature reviews. Genetics2025200 einflussreiche Zitationen
Over the past decade, epigenetic clocks have emerged as powerful machine learning tools, not only to estimate chronological and biological age but also to assess the efficacy of anti-ageing, cellular rejuvenation and disease-preventive…
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations.
Ageing Res Rev2024n=299Meta-Analysis94 einflussreiche Zitationen
Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on…
Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging.
GeroScience202476 einflussreiche Zitationen
DNA methylation (DNAm) clocks hold promise for measuring biological age, useful for guiding clinical interventions and forensic identification. This study compared the commonly used DNAm clocks, using DNA methylation and SNP data generated…
Multi-omic underpinnings of heterogeneous aging across multiple organ systems.
Cell genomics202520 einflussreiche Zitationen
Aging is the main determinant of chronic diseases and mortality, yet organ-specific aging trajectories vary, and the molecular basis underlying this heterogeneity remains unclear. To elucidate this, we integrated genomic, epigenomic,…
The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases.
Biochimica et biophysica acta. Molecular basis of disease20264 einflussreiche Zitationen
Biological aging is a complex, multifaceted process characterized by the progressive erosion of cellular homeostasis, driven by intersecting pathways of inflammaging, immune senescence, mitochondrial dysfunction, and genomic instability.…
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.
Nature communications2025n=18.8594 einflussreiche Zitationen
Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a…
Measuring biological age: Insights from omics studies.
Ageing research reviews20263 einflussreiche Zitationen
Biological ageing is a systemic, multifactorial process driven by progressive molecular and cellular alterations whose complexity necessitates systems-level approaches. Advances in high-throughput omics technologies now allow simultaneous…
Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial.
Nature medicine2026n=9583 einflussreiche Zitationen
Large-scale randomized trials have found that multivitamin-multimineral (MVM) supplements and cocoa flavanols may benefit several age-related chronic conditions among older adults, but it remains unclear whether these two supplements…
Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.
Biopsychosocial science and medicine2025n=1.2053 einflussreiche Zitationen
<h4>Objective</h4>To quantify the association between neighborhood opportunity and biological aging as measured by epigenetic clocks.<h4>Methods</h4>This cross-sectional study pooled data from 1205 participants in the Midlife in the United…
Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity.
BMC medicine2025n=3.3123 einflussreiche Zitationen
<h4>Background</h4>Previous studies reported mixed findings in the relationship between body mass index (BMI) and epigenetic age acceleration (EAA), while none considered long-term trajectory of BMI and individuals' genetic background.…