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Longevity

AMPK ActivatorsStudienlage & Dosis

Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.

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Studienlage in Zahlen

Studien gesamt
1.000
Mit Abstract
50
Meta / Systematic / RCT
76
Häufig zitiert
50
Erscheinungsjahre
1992–2026

AMPK Activators im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu AMPK Activators

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

    Reprod Biol Endocrinol2023n=169meta132 einflussreiche Zitationen

    BACKGROUND: Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects. OBJECTIVE: Inositols have…

  2. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review.

    J Transl Med2024n=811Meta-Analysis103 einflussreiche Zitationen

    <h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence…

  3. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.

    Cells2021Systematic Review84 einflussreiche Zitationen

    5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism…

  4. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    Front Immunol2022n=2.173meta77 einflussreiche Zitationen

    BACKGROUND: Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent…

  5. A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis.

    Int J Mol Sci2025n=28Systematic Review75 einflussreiche Zitationen

    Osteoporosis is a prevalent metabolic bone disorder characterized by decreased bone mineral density and increased fracture risk, particularly among aging populations. While conventional pharmacological treatments exist, they often have…

  6. A systematic review on anti-diabetic plant essential oil compounds: Dietary sources, effects, molecular mechanisms, and safety.

    Crit Rev Food Sci Nutr2024Systematic Review72 einflussreiche Zitationen

    Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic syndrome defined through the dysfunction of pancreatic β-cells driven by a confluence of genetic and environmental elements. Insulin resistance, mediated by interleukins and other…

  7. Targeting AMPK with Irisin: Implications for metabolic disorders, cardiovascular health, and inflammatory conditions - A systematic review.

    Life Sci2025Systematic Review68 einflussreiche Zitationen

    Irisin-based interventions have gained attention for their potential to modulate the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway in various diseases. Physiologically, irisin is a myokine released during physical…

  8. The effect of Berberine on weight loss in order to prevent obesity: A systematic review.

    Biomed Pharmacother2020systematic60 einflussreiche Zitationen

    This study provides a critical overview of experimental studies in vitro, in humans, and in animals that evaluated the efficacy of Berberine and its effect on management of obesity and the related metabolic consequences. As a result of…

  9. The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Oxid Med Cell Longev2021n=4.158meta60 einflussreiche Zitationen

    OBJECTIVE: Rhizoma Coptidis is an herb that has been frequently used in many traditional formulas for the treatment of diabetic mellitus (DM) over thousands of years. Berberine, the main active component of Rhizoma Coptidis, has been…

  10. Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway.

    BMC Cancer2024n=111Systematic Review60 einflussreiche Zitationen

    <h4>Background</h4>Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy and have significant adverse effects. Therefore, it is essential to establish…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Inositols (myoinositol, D-chiro-inositol, or combinations) (Varied across trials; e.g., myoinositol 1000-4000 mg/day, D-chiro-inositol 600-1200 mg/day, combinations such as MI 1100 mg + DCI 27.6 mg) • Berberine (Not reported) • AICAr (5-Aminoimidazole-4-carboxamide ribonucleoside) (not reported)
Gibt es Sicherheitshinweise zu AMPK Activators?
• Inositol vs placebo: four studies reported no side effects. • Inositol had fewer side effects than metformin (7% vs 53%). • Reported metformin adverse effects were bloating, nausea, and generalized weakness. • Mild gastrointestinal adverse events were reported.

Weitere Themen in Longevity

Zone 2

Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.

Rapamycin

mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Autophagie

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Berberin

Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.

Biologisches Alter

GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.

Caloric Restriction

CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.

Krebsfrüherkennung

Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).

Zelluläre Seneszenz

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Demenz-Prävention

Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.

DEXA-Knochendichte

DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.

Epigenetische Uhren

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Epigenetik

DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.

Exosomen

Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.

Genetiktests

Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.

Glycin

Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.

Griffkraft

Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.

Hallmarks of Aging

Genomische Instabilität, Telomer-Verkürzung, epigenetische Veränderungen, etc.

Verwandte Themen aus anderen Welten

Recovery

Active Recovery

Niedrig-Intensität, Lactate-Clearance und Trainings-Periodisierung.

Recovery

Muskelkater

Delayed Onset Muscle Soreness — Mechanismus, was hilft, was nicht.

Recovery

Load Management

Sport-spezifische Belastungs-Steuerung — Verletzungs-Prävention.

Recovery

Power Nap

10-20 min als Energie-Booster, längere Naps können Schlaf stören.

Recovery

Trainings-Stress

TSS, akute vs. chronische Belastung, ATL/CTL/TSB-Konzept.

Schlaf

Apigenin (Schlaf)

Flavonoid aus Kamille, GABA-Modulation, Schlafqualität.