Longevity

AutophagieStudienlage & Dosis

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 47
Meta / Systematic / RCT: 0
Häufig zitiert: 11
Erscheinungsjahre: 1977–2026

Autophagie im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

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Top-Studien zu Autophagie

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Nature genetics2004200 einflussreiche Zitationen
Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in intracellular aggregates. Here we show that mammalian target of…
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.
The EMBO journal2007200 einflussreiche Zitationen
Autophagy is a major catabolic pathway by which eukaryotic cells degrade and recycle macromolecules and organelles. This pathway is activated under environmental stress conditions, during development and in various pathological situations.…
Protein turnover via autophagy: implications for metabolism.
Annual review of nutrition2007141 einflussreiche Zitationen
Autophagy is a process of cellular "self-eating" in which portions of cytoplasm are sequestered within double-membrane cytosolic vesicles termed autophagosomes. The autophagosome cargo is delivered to the lysosome, broken down, and the…
Autophagy and aging: the importance of maintaining "clean" cells.
Autophagy2005141 einflussreiche Zitationen
A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related…
TOR-dependent control of autophagy: biting the hand that feeds.
Current opinion in cell biology201046 einflussreiche Zitationen
Induction of autophagy in response to starvation is a highly conserved ability of eukaryotic cells, indicating a crucial and ancient role of this process in adapting to nutrient conditions. The target of rapamycin (TOR) pathway is major…
Chaperone-mediated autophagy: selectivity pays off.
Trends in endocrinology and metabolism: TEM201042 einflussreiche Zitationen
Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic…
Autophagy Dysregulation in Metabolic Associated Fatty Liver Disease: A New Therapeutic Target.
International journal of molecular sciences2022n=832D39 einflussreiche Zitationen
Metabolic associated fatty liver disease (MAFLD) is one of the most common causes of chronic liver disease worldwide. To date, there is no FDA-approved treatment, so there is an urgent need to determine its pathophysiology and underlying…
Curcumin targets YAP1 to enhance mitochondrial function and autophagy, protecting against UVB-induced photodamage.
Front Immunol2025n=5Study39 einflussreiche Zitationen
BACKGROUND: Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin damage via DNA damage, oxidative stress, inflammation, and collagen degradation. It penetrates the epidermis, disrupts DNA integrity, and…
Autophagy: a necessary evil in cancer and inflammation.
202428 einflussreiche Zitationen
Autophagy, a highly regulated cellular process, assumes a dual role in the context of cancer. On the one hand, it functions as a crucial homeostatic pathway, responsible for degrading malfunctioning molecules and organelles, thereby…
Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy.
J Cell Biochem2023Study12 einflussreiche Zitationen
Elsinochrome A (EA) is a perylene quinone natural photosensitizer, photosensitizer under light excitation generates reactive oxygen species (ROS) to induce apoptosis, so can be used for treating tumors, that is so-called photodynamic…

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Für welche Population gilt die Evidenz?

Die meisten Studien untersuchten: animal; unknown.

Gibt es Sicherheitshinweise zu Autophagie?

• Verteporfin blocked curcumin's protective effects in mechanistic assays. • No adverse events were reported for curcumin or UVB protocols. • UVB exposure itself caused marked skin and cellular injury in both models. • Not reported.