LL-37Studienlage & Dosis

Top-Studien zu LL-37

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

   The Journal of clinical investigation·2003169 einflussreiche Zitationen

   Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial…

2. 02

   LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases.

   Biomolecules·2024153 einflussreiche Zitationen

   Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor proteins, which are further processed to…

3. 03

   Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

   The Journal of experimental medicine·2009·n=11135 einflussreiche Zitationen

   Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the endosomal seclusion of nucleic acid-recognizing Toll-like receptors (TLRs). In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that is…

4. 04

   Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

   The Biochemical journal·1999124 einflussreiche Zitationen

   The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic alpha-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence against local infection…

5. 05

   Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.

   The Journal of biological chemistry·2008107 einflussreiche Zitationen

   As a key component of the innate immunity system, human cathelicidin LL-37 plays an essential role in protecting humans against infectious diseases. To elucidate the structural basis for its targeting bacterial membrane, we have determined…

6. 06

   Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.

   Antimicrobial agents and chemotherapy·2004106 einflussreiche Zitationen

   Cathelicidin LL-37 is one of the few human bactericidal peptides with potent antistaphylococcal activity. In this study we examined the susceptibility of LL-37 to proteolytic degradation by two major proteinases produced by Staphylococcus…

7. 07

   Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.

   Antimicrobial agents and chemotherapy·199842 einflussreiche Zitationen

   Human neutrophils contain two structurally distinct types of antimicrobial peptides, beta-sheet defensins (HNP-1 to HNP-4) and the alpha-helical peptide LL-37. We used radial diffusion assays and an improved National Committee for Clinical…

8. 08

   The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent.

   Antibiotics (Basel, Switzerland)·20216 einflussreiche Zitationen

   The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from…

9. 09

   Wound healing activity of the human antimicrobial peptide LL37.

   Peptides·20114 einflussreiche Zitationen

   Antimicrobial peptides (AMPs) are part of the innate immune system and are generally defined as cationic, amphipathic peptides, with less than 50 amino acids, including multiple arginine and lysine residues. The human cathelicidin…

10. 10

    Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.

    Journal of leukocyte biology·20144 einflussreiche Zitationen

    LL-37/hCAP-18 is the only human member of the cathelicidin family and plays an important role in killing various pathogens, as well as in immune modulation. In this study, we investigated the effect of LL-37 on bacterial phagocytosis by…