HexarelinStudienlage & Dosis

Top-Studien zu Hexarelin

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Hypoglycemia: a potent stimulus to secretion of growth hormone.

   Science (New York, N.Y.)·1963200 einflussreiche Zitationen

   In normal subjects, hypoglycemia produces an abrupt and sustained rise in levels of human growth hormone in plasma. This effect is independent of insulin, glucagon, or epinephrine. Prolonged fasting is accompanied by a rise in the hormone…

2. 02

   Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone¹

   The Journal of Clinical Endocrinology & Metabolism·2001120 einflussreiche Zitationen

   An endogenous ligand for the GH secretagogue-receptor (GHS-receptor) has recently been isolated, from both the rat and the human stomach, and named ghrelin. It is a 28-amino-acid peptide showing a unique structure with an n-octanoyl ester…

3. 03

   Regulation of muscle mass by growth hormone and IGF-I.

   British journal of pharmacology·200891 einflussreiche Zitationen

   Growth hormone (GH) is widely used as a performance-enhancing drug. One of its best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I), which is primarily of hepatic origin. It also induces…

4. 04

   Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man.

   Diabetologia·198964 einflussreiche Zitationen

   To elucidate the short-term actions of growth hormone on insulin sensitivity and forearm metabolism, we have studied six normal male subjects receiving a 6-h hyperinsulinaemic euglycemic clamp with and without a concomitant 4-h growth…

5. 05

   Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man.

   The Journal of clinical endocrinology and metabolism·199050 einflussreiche Zitationen

   Primarily by increasing the availability of lipid intermediates, GH is likely to have profound effects on substrate consumption rates. To examine the short term actions of GH on glucose turnover, fuel oxidation and regional forearm…

6. 06

   Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans.

   The American journal of physiology·199140 einflussreiche Zitationen

   To examine the insulin antagonistic effects of growth hormone (GH), seven healthy subjects underwent, in random order, two 5-h euglycemic clamp studies with moderate hyperinsulinemia. A GH infusion (45 ng.kg-1.min-1) was given throughout…

7. 07

   Demonstration of a role for growth hormone in glucose counterregulation.

   The American journal of physiology·198940 einflussreiche Zitationen

   To test the hypothesis that growth hormone secretion plays a counterregulatory role in prolonged hypoglycemia in humans, four studies were performed in nine normal subjects. Insulin (15 mU.M-2.min-1) was infused subcutaneously (plasma…

8. 08

   Once upon a time: the glucagon stimulation test in diagnosing adult GH deficiency.

   Journal of endocrinological investigation·202440 einflussreiche Zitationen

   <h4>Purpose</h4>The clinical features of adult GH deficiency (GHD) are nonspecific, and its diagnosis is established through GH stimulation testing, which is often complex, expensive, time-consuming and may be associated with adverse side…

9. 09

   Route of estrogen administration helps to determine growth hormone (GH) replacement dose in GH-deficient adults.

   The Journal of clinical endocrinology and metabolism·1999·n=1337 einflussreiche Zitationen

   We prospectively studied two groups of GH-deficient patients during GH therapy based upon exposure of the liver to elevated (oral estrogen) or not elevated (endogenous or transdermal) sources of estrogen. We wondered whether higher…

10. 10

    Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?

    Current Neuropharmacology·202537 einflussreiche Zitationen

    Ghrelin is a gut peptide hormone associated with feeding behavior and energy homeostasis. Acylated ghrelin binds to the growth hormone secretagogue receptor 1a subtype (GHS-R1a) in the hippocampus, leading to GH release from the anterior…