HexarelinEvidence & Dosage
GH releaser, fast tolerance build-up, cardiac signals.
Evidence at a glance
- Total studies
- 255
- With abstract
- 49
- Meta / Systematic / RCT
- 3
- Highly cited
- 50
- Publication years
- 1963–2026
Hexarelin in the context of Peptides
This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to PeptidesTop studies on Hexarelin
Ranked by influential-citation count and publication year.
Hypoglycemia: a potent stimulus to secretion of growth hormone.
Science (New York, N.Y.)1963200 influential citationsIn normal subjects, hypoglycemia produces an abrupt and sustained rise in levels of human growth hormone in plasma. This effect is independent of insulin, glucagon, or epinephrine. Prolonged fasting is accompanied by a rise in the hormone…
Endocrine Activities of Ghrelin, a Natural Growth Hormone Secretagogue (GHS), in Humans: Comparison and Interactions with Hexarelin, a Nonnatural Peptidyl GHS, and GH-Releasing Hormone<sup>1</sup>
The Journal of Clinical Endocrinology & Metabolism2001120 influential citationsAn endogenous ligand for the GH secretagogue-receptor (GHS-receptor) has recently been isolated, from both the rat and the human stomach, and named ghrelin. It is a 28-amino-acid peptide showing a unique structure with an n-octanoyl ester…
Regulation of muscle mass by growth hormone and IGF-I.
British journal of pharmacology200891 influential citationsGrowth hormone (GH) is widely used as a performance-enhancing drug. One of its best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I), which is primarily of hepatic origin. It also induces…
Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man.
Diabetologia198964 influential citationsTo elucidate the short-term actions of growth hormone on insulin sensitivity and forearm metabolism, we have studied six normal male subjects receiving a 6-h hyperinsulinaemic euglycemic clamp with and without a concomitant 4-h growth…
Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man.
The Journal of clinical endocrinology and metabolism199050 influential citationsPrimarily by increasing the availability of lipid intermediates, GH is likely to have profound effects on substrate consumption rates. To examine the short term actions of GH on glucose turnover, fuel oxidation and regional forearm…
Effects of growth hormone on fuel utilization and muscle glycogen synthase activity in normal humans.
The American journal of physiology199140 influential citationsTo examine the insulin antagonistic effects of growth hormone (GH), seven healthy subjects underwent, in random order, two 5-h euglycemic clamp studies with moderate hyperinsulinemia. A GH infusion (45 ng.kg-1.min-1) was given throughout…
Demonstration of a role for growth hormone in glucose counterregulation.
The American journal of physiology198940 influential citationsTo test the hypothesis that growth hormone secretion plays a counterregulatory role in prolonged hypoglycemia in humans, four studies were performed in nine normal subjects. Insulin (15 mU.M-2.min-1) was infused subcutaneously (plasma…
Once upon a time: the glucagon stimulation test in diagnosing adult GH deficiency.
Journal of endocrinological investigation202440 influential citations<h4>Purpose</h4>The clinical features of adult GH deficiency (GHD) are nonspecific, and its diagnosis is established through GH stimulation testing, which is often complex, expensive, time-consuming and may be associated with adverse side…
Route of estrogen administration helps to determine growth hormone (GH) replacement dose in GH-deficient adults.
The Journal of clinical endocrinology and metabolism1999n=1337 influential citationsWe prospectively studied two groups of GH-deficient patients during GH therapy based upon exposure of the liver to elevated (oral estrogen) or not elevated (endogenous or transdermal) sources of estrogen. We wondered whether higher…
Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?
Current Neuropharmacology202537 influential citationsGhrelin is a gut peptide hormone associated with feeding behavior and energy homeostasis. Acylated ghrelin binds to the growth hormone secretagogue receptor 1a subtype (GHS-R1a) in the hippocampus, leading to GH release from the anterior…
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