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LiraglutideEvidence & Dosage

First-generation GLP-1 for diabetes/obesity — daily, smaller effect size.

Evidence at a glance

Total studies
816
With abstract
48
Meta / Systematic / RCT
4
Highly cited
7
Publication years
1999–2026

Liraglutide in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Liraglutide

Ranked by influential-citation count and publication year.

  1. Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial

    Nature Medicine2025n=204120 influential citations

    Liraglutide, a glucagon-like peptide 1 (GLP-1) agonist and antidiabetic drug, has shown neuroprotective effects in animal models. In this study, we aimed to evaluate the safety and efficacy of liraglutide in mild to moderate Alzheimer's…

  2. Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects.

    Behavioural brain research201737 influential citations

    Diabetes has been identified as a risk factor for cognitive dysfunctions. Glucagone like peptide 1 (GLP-1) receptor agonists have neuroprotective effects in preclinical animal models. We evaluated the effects of GLP-1 receptor agonist,…

  3. Systemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study

    Gut Microbes202524 influential citations

    Metformin (Met) and liraglutide (Lira) are preferred diabetes therapies that may improve glycemia by modulating the gut microbiome, but the mechanisms and pathways are unknown and few data exist in youth-onset type 2 diabetes (Y-T2D). In a…

  4. Liraglutide alleviates ferroptosis in renal ischemia reperfusion injury via inhibiting macrophage extracellular trap formation

    International Immunopharmacology202423 influential citations

    <h4>Background and purpose</h4>Renal transplantation and other conditions with transiently reduced blood flow is major cause of renal ischemia/reperfusion injury (RIRI), a therapeutic challenge clinically. This study investigated the role…

  5. Liraglutide suppresses ferroptosis by upregulation NRF2 in type 2 diabetic cardiomyopathy

    Peptides202520 influential citations

    Recent research indicates that inhibiting myocardial ferroptosis may help alleviate diabetic cardiomyopathy (DCM). Liraglutide (LIRA), a glucagon-like peptide-1 receptor agonist, has been shown to offer cardiovascular protective effects.…

  6. Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

    bioRxiv202312 influential citations

    Liraglutide and other agonists of the glucagon-like peptide 1 receptor (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. One potential mechanism is by activating neurons which inhibit…

  7. Liraglutide attenuates clozapine-induced mitochondrial dysfunction and improves energy metabolism in the brain of rats

    Biochemical Pharmacology2025n=73 influential citations

    Chronic use of antipsychotics for schizophrenia (SCZ) often causes metabolic disturbances that exacerbate cognitive impairment, and the underlying mechanisms remain unclear. As a classic antipsychotic, the metabolic toxicity of clozapine…

  8. Unveiling the potential therapeutic role of nifuroxazide and liraglutide combination in mitigating LPS-induced acute lung injury through modulation of AT1R/JAK-2/STAT-3 by ACE2/ Ang1‐7/MasR signaling in male albino rats: in vivo and in silico study

    International Immunopharmacology20253 influential citations

    The current study investigated the possible therapeutic role of a combination of liraglutide and nifuroxazide in ameliorating the JAK2/STAT3/NFĸB signaling pathway by augmenting the counter-regulatory ACE2/Ang1-7/MAS receptor axis of the…

  9. A Pharmacological Dose of Liraglutide Improves Mitochondrial Performance in Mouse Leydig Cells

    International Journal of Molecular Sciences20253 influential citations

    Male fertility has declined over the years, partly due to metabolic disorders such as obesity and Type 2 diabetes. Antidiabetic drugs, including GLP-1 receptor agonists like liraglutide, are widely used to manage these conditions and aid…

  10. The novel GLP-1 / GIP dual agonist DA3-CH is more effective than liraglutide in the MPTP mouse model of Parkinson's disease

    European Journal of Pharmacology20253 influential citations

    Parkinson's disease is the second most common neurodegenerative disease worldwide with a high incidence rate. The abnormality of the Wnt/β-catenin signaling pathway is closely related to the occurrence of Parkinson's disease (PD).…

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