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Cognition

Glucose vs KetonesEvidence & Dosage

The brain's fuel sources, ketogenic adaptation, cognitive effects.

Evidence at a glance

Total studies
442
With abstract
50
Meta / Systematic / RCT
1
Highly cited
50
Publication years
1967–2026

Glucose vs Ketones in the context of Cognition

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Top studies on Glucose vs Ketones

Ranked by influential-citation count and publication year.

  1. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes.

    Diabetes/metabolism research and reviews1999200 influential citations

    Ketone bodies are produced by the liver and used peripherally as an energy source when glucose is not readily available. The two main ketone bodies are acetoacetate (AcAc) and 3-beta-hydroxybutyrate (3HB), while acetone is the third, and…

  2. Effect of ketone infusions on amino acid and nitrogen metabolism in man.

    The Journal of clinical investigation1975122 influential citations

    To evaluate the role of hyperketonemia in the hypoalaninemia and decreased protein catabolism of prolonged starvation, Na dl-beta-hydroxybutyrate was administered as a primed continuous 3-6-h infusion in nonobese subjects and in obese…

  3. Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload-Induced Heart Failure.

    Circulation. Heart failure201753 influential citations

    Background Energy starvation and the shift of energy substrate from fatty acids to glucose is the hallmark of metabolic remodeling during heart failure progression. However, ketone body metabolism in the failing heart has not been fully…

  4. Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

    Molecular metabolism2014n=1050 influential citations

    <h4>Objective</h4>Exploitation of protective metabolic pathways within injured myocardium still remains an unclarified therapeutic target in heart disease. Moreover, while the roles of altered fatty acid and glucose metabolism in the…

  5. Ketone-body production and oxidation in fasting obese humans.

    The Journal of clinical investigation197439 influential citations

    Rates of plasma acetoacetate and total ketone-body production and oxidation to CO2 were determined by an isotope tracer technique in eight obese subjects undergoing progressive starvation. After a brief fast and under conditions of mild…

  6. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?

    Diabetes care200839 influential citations

    <h4>Objective</h4>Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO(3)] and pH) and qualitative nature (the presence of ketonemia/ketonuria). The present study was…

  7. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.

    American journal of physiology. Regulatory, integrative and comparative physiology2013n=6038 influential citations

    Central nervous system oxygen toxicity (CNS-OT) seizures occur with little or no warning, and no effective mitigation strategy has been identified. Ketogenic diets (KD) elevate blood ketones and have successfully treated drug-resistant…

  8. Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals.

    The American journal of clinical nutrition200236 influential citations

    <h4>Background</h4>Ketogenic diets are used therapeutically to treat intractable seizures. Clinically, it appears that the maintenance of ketosis is crucial to the efficacy of the diet in ameliorating seizures. To understand how ketosis…

  9. Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.

    Diabetes201635 influential citations

    Identifying markers of human insulin resistance may permit development of new approaches for treatment and prevention of type 2 diabetes. To this end, we analyzed the fasting plasma metabolome in metabolically characterized human…

  10. Neuronal-glial interactions in rats fed a ketogenic diet.

    Neurochemistry international200632 influential citations

    Glucose is the preferred energy substrate for the adult brain. However, during periods of fasting and consumption of a high fat, low carbohydrate (ketogenic) diet, ketone bodies become major brain fuels. The present study was conducted to…

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