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Citicoline (CDP-Choline)Evidence & Dosage

Phospholipid synthesis, ADHD, and neurological applications.

Studies last updated

Evidence at a glance

Total studies
535
With abstract
49
Meta / Systematic / RCT
104
Highly cited
50
Publication years
1980–2026

Citicoline (CDP-Choline) in the context of Cognition

This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Citicoline (CDP-Choline)

Ranked by influential-citation count and publication year.

  1. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

    Lancet2012n=229RCT66 influential citations

    <h4>Background</h4>Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger…

  2. Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.

    Journal of clinical medicine2024D60 influential citations

    In recent years, researchers have been interested in neuroprotective therapies as a cutting-edge therapeutic strategy to treat neurodegenerative disorders by shielding the brain system from harmful events. Millions of individuals worldwide…

  3. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT).

    JAMA2012n=121RCT54 influential citations

    <h4>Context</h4>Traumatic brain injury (TBI) is a serious public health problem in the United States, yet no treatment is currently available to improve outcome after TBI. Approved for use in TBI in 59 countries, citicoline is an…

  4. A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

    Neurology1997n=259RCT52 influential citations

    Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both animal models and non-US clinical stroke…

  5. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators.

    Ann Neurol2000n=100RCT48 influential citations

    We examined the effect of the neuroprotective and neuroreparative agent citicoline on the growth of cerebral ischemic lesions in a double-blind placebo-controlled study involving patients with acute ischemic stroke using diffusion-weighted…

  6. Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis.

    Front Neurosci2024n=12,210Systematic Review47 influential citations

    <h4>Background</h4>Ischemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. While reperfusion therapies play a critical role in the management of acute ischemic stroke…

  7. A randomized efficacy trial of citicoline in patients with acute ischemic stroke.

    Stroke1999n=394RCT46 influential citations

    <h4>Background and purpose</h4>Citicoline (cytidine-5'-diphosphocholine; CDP-choline) may reduce central nervous system ischemic injury by stabilizing cell membranes and reducing free radical generation. A previous dose-comparison trial in…

  8. Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials.

    Stroke2002n=165Meta-Analysis42 influential citations

    <h4>Background and purpose</h4>No single neuroprotective agent has been shown to influence outcome after acute stroke. Citicoline has been studied worldwide in many clinical trials with positive findings, but only 1 trial has obtained…

  9. Application of Citicoline in Neurological Disorders: A Systematic Review.

    Nutrients2020n=47systematic41 influential citations

    Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely…

  10. Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology2024D39 influential citations

    Citicoline, a compound produced naturally in small amounts in the human body, assumes a pivotal role in phosphatidylcholine synthesis, a dynamic constituent of membranes of neurons. Across diverse models of brain injury and…

Frequently asked

What dosage was studied?
• Citicoline (1000 mg every 12 h intravenously during the first 3 days, then 500 mg oral tablets every 12 h thereafter) • Citicoline (2000 mg daily, enteral or oral)
Are there safety considerations for Citicoline (CDP-Choline)?
• No significant differences in safety variables were reported. • No significant differences in adverse event rates were reported. • Symptomatic intracranial haemorrhage was a prespecified safety endpoint in rt-PA-treated patients. • Not reported in the abstract.

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