Alpha-GPCEvidence & Dosage

Top studies on Alpha-GPC

Ranked by influential-citation count and publication year.

1. 01

   Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501).

   Mol Psychiatry·2023·n=150Meta-Analysis122 influential citations

   Evidence suggests that neurometabolite alterations may be involved in the pathophysiology of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic resonance spectroscopy (¹H-MRS) studies to examine…

   Finding: Compared with healthy controls, patients with autism spectrum disorders had lower NAA and glutamate + glutamine (Glx) levels in white matter.

2. 02

   Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis.

   Eur J Nucl Med Mol Imaging·2019·n=517Meta-Analysis120 influential citations

   <h4>Purpose</h4>Hyperparathyroidism (HPT) is a common endocrine disorder caused by hyperfunctioning parathyroid glands (HP). The correct detection and localization of HP is challenging but crucial, as it may guide surgical treatment,…

   Finding: On a per-lesion basis, pooled sensitivity and positive predictive value were both 92%.

3. 03

   The role of 11C-choline and 18F-fluorocholine positron emission tomography (PET) and PET/CT in prostate cancer: a systematic review and meta-analysis.

   Eur Urol·2013·n=637Meta-Analysis94 influential citations

   <h4>Context</h4>The role of positron emission tomography (PET) and PET/computed tomography (PET/CT) in prostate cancer (PCa) imaging is still debated, although guidelines for their use have emerged over the last few…

   Finding: In staging patients with proven but untreated prostate cancer, 11C-choline and 18F-fluorocholine PET/PET/CT had pooled per-patient sensitivity of 84% and specificity of 79%.

4. 04

   Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis.

   Skeletal Radiol·2014·n=16Meta-Analysis93 influential citations

   Published data on the diagnosis of bone metastases of prostate cancer are conflicting and heterogeneous. We performed a comprehensive meta-analysis to compare the diagnostic performance of choline-PET/CT, MRI, bone SPECT, and bone…

   Finding: The meta-analysis concluded that MRI was better than choline PET/CT and bone scintigraphy on a per-patient basis, while choline PET/CT was better than bone SPECT and bone scintigraphy on a per-lesion basis.

5. 05

   (68)Ga-Labeled Prostate-specific Membrane Antigen Ligand Positron Emission Tomography/Computed Tomography for Prostate Cancer: A Systematic Review and Meta-analysis.

   Eur Urol Focus·2018·n=125Meta-Analysis84 influential citations

   <h4>Context</h4>⁶⁸Gallium prostate-specific membrane antigen (PSMA) ligand ⁶⁸Ga-HBED-CC-PSMA (⁶⁸Ga-PSMA) is a promising radiotracer for positron emission tomography (PET)/computed tomography (CT) of…

6. 06

   Choline PET or PET/CT and biochemical relapse of prostate cancer: a systematic review and meta-analysis.

   Clin Nucl Med·2013·n=155Meta-Analysis77 influential citations

   <h4>Aim</h4>The increase of prostate-specific antigen (PSA) after radical retropubic prostatectomy (RP) or external beam radiotherapy (EBRT) is the most sensitive tool for detecting prostate cancer (PCa) recurrence, although this measure…

   Finding: In men with biochemical recurrence of prostate cancer, choline PET or PET/CT showed high pooled diagnostic accuracy for detecting disease at all sites.

7. 07

   (18)F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literature.

   Ann Nucl Med·2020·n=111Systematic Review70 influential citations

   The aims of the present systematic review were to: (1) assess the role of 18 F-fluorocholine (FCH) positron emission tomography (PET) with computed tomography (CT) and PET with magnetic resonance imaging (MRI) in patients with…

8. 08

   Utility of choline positron emission tomography/computed tomography for lymph node involvement identification in intermediate- to high-risk prostate cancer: a systematic literature review and meta-analysis.

   Eur Urol·2013·n=441Meta-Analysis68 influential citations

   <h4>Context</h4>Determination of tumour involvement of regional lymph nodes in patients with prostate cancer (PCa) is of key importance for the proper planning of treatment.<h4>Objectives</h4>To provide a critical overview of published…

9. 09

   PET/CT with (11)C-choline for evaluation of prostate cancer patients with biochemical recurrence: meta-analysis and critical review of available data.

   Eur J Nucl Med Mol Imaging·2016·n=2,686Meta-Analysis66 influential citations

   <h4>Purpose</h4>For the last decade PET and PET/CT with (11)C-choline have been proposed for the evaluation of prostate cancer (PC), but the diagnostic performance of (11)C-choline PET/CT is still a matter of debate. We performed a…

10. 10

    Meta-analysis of the effects of supplemental rumen-protected choline during the transition period on performance and health of parous dairy cows.

    J Dairy Sci·2020·n=1,313Meta-Analysis64 influential citations

    The objectives were to use meta-analytic methods to determine the effects of amount of supplemental choline ion as rumen-protected choline (RPC) starting prepartum on production and health of dairy cows. The literature was systematically…

    Finding: Supplementing choline during transition had no effect on metritis, milk fever, displaced abomasum, ketosis, or hepatic triacylglycerol concentration postpartum.

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