SerotoninEvidence & Dosage
Mood, sleep, appetite, the gut — 90% is produced in the gut.
Evidence at a glance
- Total studies
- 836
- With abstract
- 41
- Meta / Systematic / RCT
- 1
- Highly cited
- 10
- Publication years
- 1983–2026
Serotonin in the context of Mental
This topic is part of our "Mental" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to MentalTop studies on Serotonin
Ranked by influential-citation count and publication year.
Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists.
Brain research bulletin200162 influential citations5-Hydroxytryptamine(2A) (serotonin(2A), 5-HT(2A)) receptors are important for many physiologic processes including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. A large number of pharmaceutical…
Sex difference in 5HT2 receptor in the living human brain.
Neuroscience letters199652 influential citationsSerotonergic mechanisms are involved in gender-related behaviors and psychiatric conditions like aggression, eating disorders, depression, impulsivity or suicide. We studied gender differences in the living human brain type-2 serotonin…
A review of the role of serotonin receptors in psychiatric disorders.
Human psychopharmacology200050 influential citationsSerotonin (5-hydroxytryptamine, 5-HT) mediates a wide variety of physiological functions by activating multiple receptors, and abnormalities of these receptor systems has been implicated in many psychiatric disorders including anxiety,…
An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish.
Comp Biochem Physiol C Toxicol Pharmacol2017review42 influential citationsPharmaceuticals and personal care products (PPCPs) are found in measureable quantities within the aquatic environment. Selective serotonin reuptake inhibitor (SSRI) antidepressants are one class of pharmaceutical compound that has received…
Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents.
Life sciences199141 influential citationsIn order to establish a functional role for the various populations of serotonin (5-HT) receptors, behavioral studies have been conducted over the past decade with serotonergic agonists and antagonists. And, although there is reason to…
SSRI-induced apathy syndrome: a clinical review.
Journal of psychiatric practice200433 influential citationsThe authors review the literature pertaining to selective serotonin reuptake inhibitor (SSRI)-induced apathy syndrome. A literature search of Medline and International Pharmaceutical Abstracts from 1970 to the present was performed for…
Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
Neuron200622 influential citationsThe neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT1BRs), modulates the endogenous release…
HTR2A: association and expression studies in neuropsychiatric genetics.
Annals of medicine200519 influential citationsOver the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder…
Selective serotonin reuptake inhibitor exposure.
Top Companion Anim Med2013review17 influential citationsMany antidepressants inhibit serotonin or norepinephrine reuptake or both to achieve their clinical effect. The selective serotonin reuptake inhibitor class of antidepressants (SSRIs) includes citalopram, escitalopram (active enantiomer of…
Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons.
European journal of pharmacology201015 influential citationsThe serotonin transporter (SERT) terminates serotonergic neurotransmission by the rapid removal of serotonin (5-hydroxytryptamine, 5-HT) from the extracellular space back into serotonergic neurons. SERT therefore controls the concentration…
More topics in Mental
5-HTP
Serotonin precursor, mood, and Carbidopa safety.
Anxiety
Acute anxiety vs. an anxiety disorder, the neurobiology, interventions.
Ashwagandha (Stress)
Adaptogen — cortisol lowering, sleep, anxiety reduction.
Breathwork
Box breathing, 4-7-8, Wim Hof, pranayama — autonomic regulation.
Burnout Early Signs
Exhaustion, cynicism, dropping performance — spotting it before the crash.
Caffeine & Anxiety
Adenosine antagonism, individual sensitivity, cut-off strategies.
CBT
Cognitive behavioral therapy — the gold standard for anxiety and depression.
Co-Regulation
Nervous-system regulation within relationship — attachment, therapy, parent-child.
Cold Exposure (Mood)
Norepinephrine, depression, and mood effects of cold.
Depression
Symptoms, the monoamine hypothesis, lifestyle interventions, professional help.
Depth Psychology
Psychodynamic therapy, transference, long-term change.
Doomscrolling
Algorithm-driven negative info consumption — mood effects, limits.
EMDR / Trauma Therapy
PTSD, eye movements, and study effectiveness.
Exercise as Antidepressant
Aerobic exercise — efficacy comparable to SSRIs in mild depression.
Fight/Flight/Freeze
Stress-response patterns, somatic manifestation, regulation.
Glucose & Mood
Glucose swings, reactive hypoglycemia, mood stability.
Gut-Brain Axis
Vagus nerve, short-chain fatty acids, the microbiome's influence on mood.
Journaling (Mental)
Expressive writing, gratitude — reducing stress, anxiety and depression.
L-Tryptophan
Serotonin/Melatonin, amino‑acid competition and outcomes.
Lavender
Silexan studies, oral and olfactory — anxiolysis with a good safety profile.
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HRV Tracking
Heart rate variability as a resilience and recovery indicator.
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A trend marker for cardiovascular fitness and overtraining.
Chronic Stress
Allostatic load, immune and metabolic consequences, interventions.
Endometriosis
A chronic inflammatory disease — diagnosis, options, lifestyle factors.
Hashimoto Thyroiditis
Autoimmune thyroid disease — TPO/TG antibodies, selenium, iodine caution.
Iodine
Thyroid, recommendations, caution with Hashimoto's, daily requirement.