Gut-Brain AxisEvidence & Dosage

Top studies on Gut-Brain Axis

Ranked by influential-citation count and publication year.

1. 01

   Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats.

   Psychoneuroendocrinology·2014155 influential citations

   <h4>Background and aims</h4>Establishment of the gut microbiota is one of the most important events in early life and emerging evidence indicates that the gut microbiota influences several aspects of brain functioning, including reactivity…

2. 02

   The endocannabinoid system links gut microbiota to adipogenesis.

   Molecular systems biology·2010154 influential citations

   Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that…

3. 03

   The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

   Neuro endocrinology letters·2008141 influential citations

   There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro-inflammatory cytokines and lipopolysacharide (LPS) may induce depressive symptoms. The aim of the…

4. 04

   Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.

   Gastroenterology·2010140 influential citations

   <h4>Background & aims</h4>Clinical and preclinical studies have associated gastrointestinal inflammation and infection with altered behavior. We investigated whether chronic gut inflammation alters behavior and brain biochemistry and…

5. 05

   Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology.

   Psychoneuroendocrinology·2012138 influential citations

   There is now an expanding volume of evidence to support the view that commensal organisms within the gut play a role in early programming and later responsivity of the stress system. The gut is inhabited by 10¹³-10¹⁴ micro-organisms, which…

6. 06

   The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.

   Gastroenterology·2009115 influential citations

   Although many people are aware of the communication that occurs between the gastrointestinal (GI) tract and the central nervous system, fewer know about the ability of the central nervous system to influence the microbiota or of the…

7. 07

   Maternal separation as a model of brain-gut axis dysfunction.

   Psychopharmacology·201199 influential citations

   <h4>Rationale</h4>Early life stress has been implicated in many psychiatric disorders ranging from depression to anxiety. Maternal separation in rodents is a well-studied model of early life stress. However, stress during this critical…

8. 08

   Microbes and the gut-brain axis.

   Neurogastroenterology and motility·201293 influential citations

   <h4>Background</h4>The 'gut-brain' or 'brain-gut axis', depending on whether we emphasize bottom-up or top-bottom pathways, is a bi-directional communication system, comprised of neural pathways, such as the enteric nervous system (ENS),…

9. 09

   Voices from within: gut microbes and the CNS.

   Cellular and molecular life sciences : CMLS·201375 influential citations

   Recent advances in research have greatly increased our understanding of the importance of the gut microbiota. Bacterial colonization of the intestine is critical to the normal development of many aspects of physiology such as the immune…

10. 10

    The importance of the gut microbiota after bariatric surgery.

    Nature reviews. Gastroenterology &amp; hepatology·201257 influential citations

    The gut microbiota is recognized to have an important role in energy storage and the subsequent development of obesity. To date, bariatric surgery (indicated for severe obesity) represents the only treatment that enables substantial and…