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Magnesium for SleepEvidence & Dosage

Bisglycinate, threonate, and RCT studies on sleep outcomes.

Studies last updated

Evidence at a glance

Total studies
261
With abstract
50
Meta / Systematic / RCT
116
Highly cited
50
Publication years
1954–2026

Magnesium for Sleep in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Magnesium for Sleep

Ranked by influential-citation count and publication year.

  1. Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal.

    JAMA1997meta176 influential citations

    OBJECTIVE: To provide an evidence-based practice guideline on the pharmacological management of alcohol withdrawal. DATA SOURCES: English-language articles published before July 1, 1995, identified through MEDLINE search on "substance…

    Finding: Benzodiazepines reduce alcohol withdrawal severity, delirium incidence, and seizures.

  2. Micronutrient Supplementation to Reduce Cardiovascular Risk.

    J Am Coll Cardiol2022n=883,627Systematic Review149 influential citations

    <h4>Background</h4>Healthy dietary patterns are rich in micronutrients, but their influence on cardiovascular disease (CVD) risks has not been systematically quantified.<h4>Objectives</h4>The goal of this study was to provide a…

  3. Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualitative Review.

    PLoS One2015n=61Meta-Analysis114 influential citations

    <h4>Background</h4>The use of peripheral nerve blocks for anesthesia and postoperative analgesia has increased significantly in recent years. Adjuvants are frequently added to local anesthetics to prolong analgesia following peripheral…

    Finding: The review found that perineural buprenorphine, clonidine, dexamethasone, dexmedetomidine, and magnesium most consistently prolonged peripheral nerve blocks.

  4. Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials.

    BMJ1991n=130Meta-Analysis113 influential citations

    <h4>Objective</h4>To investigate the effect of intravenous magnesium on mortality in suspected acute myocardial infarction.<h4>Design</h4>Systematic overview of all available randomised trials in which patients were allocated to receive…

  5. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature.

    Biol Trace Elem Res2023n=7,582systematic111 influential citations

    To date, no study has critically reviewed the current literature on the association between magnesium (Mg) and sleep health. Therefore, we carried out a systematic review to assess the association between Mg and sleep patterns in adults'…

  6. Tocolytics for preterm labor: a systematic review.

    Obstet Gynecol1999n=18Systematic Review103 influential citations

    <h4>Objective</h4>To examine the effectiveness of any tocolytic compared with a placebo or no tocolytic for preterm labor.<h4>Data sources</h4>We checked MEDLINE (1966-1998) and the Cochrane Controlled Trials Register for articles, using…

  7. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia.

    Anesth Analg2004n=40Systematic Review71 influential citations

    <h4>Unlabelled</h4>We evaluated in a qualitative systematic review the effect of N-methyl-D-aspartate (NMDA) receptor antagonists on reducing postoperative pain and analgesic consumption beyond the clinical duration of action of the target…

  8. Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study.

    J Affect Disord2024n=20,585other70 influential citations

    BACKGROUND: The association between magnesium status and sleep quality is unclear. The aim of this study was to determine the relationship between renal reabsorption-related magnesium depletion score (MDS) and sleep quality. METHODS: This…

  9. Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials.

    Diabet Med2006n=370Meta-Analysis56 influential citations

    <h4>Aims</h4>The aim of this study was to assess the evidence on the effect of oral magnesium supplementation on glycaemic control in patients with Type 2 diabetes.<h4>Methods</h4>We searched the electronic databases of medline, embase and…

    Finding: Oral magnesium supplementation significantly reduced post-intervention fasting glucose in patients with type 2 diabetes.

  10. Calcium channel blockers for inhibiting preterm labour and birth.

    Cochrane Database Syst Rev2014n=38Meta-Analysis55 influential citations

    <h4>Background</h4>Preterm birth is a major contributor to perinatal mortality and morbidity, affecting around 9% of births in high-income countries and an estimated 13% of births in low- and middle-income countries. Tocolytics are drugs…

Frequently asked

What does the evidence say about Magnesium for Sleep?
Benzodiazepines reduce alcohol withdrawal severity, delirium incidence, and seizures.
What dosage was studied?
• Pharmacological management of alcohol withdrawal; benzodiazepines, beta-blockers, clonidine, carbamazepine, phenothiazines/neuroleptics, and individualized therapy using withdrawal scales (Not reported in abstract) • Supplementation with 27 types of micronutrients (Not reported) • Perineural/local anesthetic peripheral nerve block adjuvants (buprenorphine, morphine, fentanyl, epinephrine, clonidine, dexmedetomidine, dexamethasone, tramadol, magnesium) (Not reported)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Magnesium for Sleep?
• Benzodiazepines are recommended for alcohol withdrawal in this guideline. • Beta-blockers, clonidine, carbamazepine, and neuroleptics are adjuncts only, not monotherapy. • β-carotene increased all-cause mortality, CVD mortality, and stroke risk. • None of the perineural adjuvants have FDA approval for this indication.

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Evidence-based overview of magnesium for sleep: What do meta-analyses and RCTs show? Which mechanisms are plausible, what remains unclear—dose & safety included.

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