IGF-1 LR3Evidence & Dosage

Top studies on IGF-1 LR3

Ranked by influential-citation count and publication year.

1. 01

   Potential roles of insulin and IGF-1 in Alzheimer's disease.

   Trends in neurosciences·200348 influential citations

   Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling…

2. 02

   Function of matrix IGF-1 in coupling bone resorption and formation.

   Journal of molecular medicine (Berlin, Germany)·201436 influential citations

   Balancing bone resorption and formation is the quintessential component for the prevention of osteoporosis. Signals that determine the recruitment, replication, differentiation, function, and apoptosis of osteoblasts and osteoclasts direct…

3. 03

   Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.

   Journal of Alzheimer's disease : JAD·2025·n=19E21 influential citations

   Insulin-like growth factor-1 (IGF-1) promotes neurogenesis, cell survival, and glial function, making it a promising candidate therapy in Alzheimer's disease (AD). Long arginine 3-IGF-1 (LR3-IGF-1) is a potent IGF-1 analogue. We sought to…

4. 04

   L-Citrulline Improves IGF-1 Signaling Pathway in Preeclampsia via Polyamines.

   Hypertension (Dallas, Tex. : 1979)·2025E3 influential citations

   Preeclampsia is a severe pregnancy complication with no effective pharmacological therapy available. We previously demonstrated that L-citrulline supplementation improves preeclampsia phenotypes in Dahl salt-sensitive rats, an animal model…

5. 05

   The IGF signaling axis in thyroid cancer: biological complexity and therapeutic challenges.

   Endocr Connect·2026Review

   Dysregulation of the insulin-like growth factor (IGF) axis plays an important role in thyroid cancer progression, dedifferentiation, and therapeutic resistance. While most differentiated thyroid cancers have favorable outcomes, a…

6. 06

   Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.

   International journal of biological macromolecules·2025·n=5

   Peripheral nerve injuries lead to significant functional deficits, with no treatment achieving complete recovery. Autologous nerve grafting remains the gold standard, but it is limited by donor site morbidity. Artificial nerve conduits…

7. 07

   Signaling Pathways of the Insulin-like Growth Factor Binding Proteins.

   Endocrine reviews·2023

   The 6 high-affinity insulin-like growth factor binding proteins (IGFBPs) are multifunctional proteins that modulate cell signaling through multiple pathways. Their canonical function at the cellular level is to impede access of…

8. 08

   The interrelationship between prostate cancer and osteoporosis: new perspectives on shared molecular pathways and treatment strategies.

   International journal of surgery (London, England)·2026E

   Osteoporosis is frequently regarded as a complication associated with androgen deprivation therapy (ADT) in patients with prostate cancer. Nevertheless, a notably higher incidence of osteoporosis has been observed in prostate cancer…

9. 09

   Assessing the Role of Lifestyle in Modulating Serum IGF-1 and Association with Breast Cancer Risk among Palestinian Women in the Gaza Strip: A Case-Control Study.

   Asian Pacific journal of cancer prevention : APJCP·2026E

   Breast cancer (BC) continues to be one of the most commonly diagnosed cancers worldwide, predominantly affecting women. Insulin-like growth factor-1 (IGF-1) is vital for cellular growth and metabolism. Dysregulation of IGF-1 has been…