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Immune ModulationEvidence & Dosage

Automatisch via Trend Scout entdeckt. Supplements targeting inflammation and immune resilience remain a central research area.. PubMed: 11956 Ergebnisse.

Studies last updated

Evidence at a glance

Total studies
429
With abstract
48
Meta / Systematic / RCT
181
Highly cited
8
Publication years
2017–2026

Immune Modulation in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Immune Modulation

Ranked by influential-citation count and publication year.

  1. Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China.

    Lancet2026n=18Clinical Trial110 influential citations

    <h4>Background</h4>Lately, autologous CD19-targeting chimeric antigen receptor (CAR) T cells have shown excellent efficacy in treatment of autoimmune diseases, but with great safety concerns, such as infections. In this study, we aimed to…

  2. Bioactive compounds in fermented foods: a systematic narrative review.

    Front Nutr2025n=50Systematic Review53 influential citations

    This systematic narrative review aims to catalogue bioactive compounds that are formed during the fermentation process and identified as contributors to positive health outcomes in human clinical studies where fermented foods were used as…

  3. Immunomodulators and Advanced Therapies for Induction of Remission in Crohn's Disease: A Systematic Review and Network Meta-Analysis.

    Inflamm Bowel Dis2026n=20,724Meta-Analysis50 influential citations

    <h4>Background</h4>Previous reviews for Crohn's disease (CD) treatment have rarely considered advanced and immunomodulator medical therapies together. Our aim was to compare all therapies for efficacy and safety in induction of…

    Finding: Upadacitinib and risankizumab were probably more effective than placebo for inducing endoscopic remission.

  4. Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models.

    Inflammopharmacology2025n=175Meta-Analysis42 influential citations

    Berberine (BBR), an alkaloid derivative mostly found in Oregon grapes and barberry shoots, has several medical properties, including anti-microbial, anti-tumorigenic, and anti-inflammatory properties. As such, it is a superior alternative…

  5. Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review.

    Nutrients2025n=45systematic32 influential citations

    Background: This systematic review aimed to evaluate the efficacy and safety of dietary supplements in breast cancer patients, focusing on their impact on clinical outcomes, treatment-related side effects, and therapy adherence. Methods:…

  6. Resveratrol in oral cancer: a systematic review of preclinical studies on its anticancer mechanisms and therapeutic potential.

    Med Oncol2025n=19Systematic Review27 influential citations

    <h4>Objective</h4>Oral cancer remains a major global health challenge due to its aggressive nature, high recurrence rates, and limited treatment options. Resveratrol (RV), a naturally occurring polyphenol, has demonstrated promising…

  7. Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: A systematic review.

    PLoS One2024n=27Systematic Review19 influential citations

    Cervical cancer ranked fourth most common malignancy among women worldwide despite the establishment of vaccination programmes. This systematic review evaluates the anti-cancer properties of turmeric and ginger bioactive compounds,…

  8. A comprehensive review of Glycyrrhiza glabra in the management of rheumatoid arthritis: ethnopharmacology, pharmacological mechanisms and synergistic therapeutic strategies.

    J Ethnopharmacol2026Systematic Review3 influential citations

    <h4>Ethnopharmacological relevance</h4>Glycyrrhiza glabra L. (Fabaceae), commonly known as liquorice, has been valued for millennia in Ayurveda, Traditional Chinese Medicine (TCM), Persian medicine, and European folk practice. Across these…

  9. Phytotherapy as an adjunct to the treatment of rheumatoid arthritis - a systematic review of clinical trials.

    Phytomedicine2025n=14Systematic Review3 influential citations

    <h4>Background</h4>Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease whose incidence is on an upward trend. The condition leads to progressive joint destruction, manifested by symptoms such as morning…

  10. Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review.

    RMD Open2025n=14Meta-Analysis3 influential citations

    <h4>Objective</h4>To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety.<h4>Methods</h4>Systematic review of randomised controlled trials (RCTs) of…

Frequently asked

What dosage was studied?
• Allogeneic CD19 CAR NK-cell therapy (Schedule escalation from 7 days; dose escalation commencing at 0.75 × 10^9 CAR NK cells on day 0; three infusions per treatment cycle with lymphodepleting fludarabine and cyclophosphamide) • Fermented foods containing bioactive compounds formed during fermentation • Immunomodulators and advanced therapies, including anti-TNFs, anti-integrins, IL-12/23p40 antagonists, IL-23p19 antagonists, JAK inhibitors, and combination therapies with azathioprine/6-mercaptopurine (Various dose regimens; doses were combined in analysis)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Immune Modulation?
• Grade 1 cytokine release syndrome occurred in 1 of 18 patients. • No neurotoxicity was observed. • No dose-limiting toxicities were reported. • Patients received lymphodepleting fludarabine and cyclophosphamide before CAR NK-cell infusions.

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Immune Modulation: Effects and Evidence — what is actually supported

Evidence-based overview of immune modulation: what 182 high-quality studies (including meta-analyses) show. Limits, strength of evidence, and practical relevance.

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