RCTEvidence & Dosage
The gold standard: randomization, blinding, placebo, statistical power.
Evidence at a glance
- Total studies
- 362
- With abstract
- 44
- Meta / Systematic / RCT
- 4
- Highly cited
- 0
- Publication years
- 2006–2026
RCT in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on RCT
Ranked by influential-citation count and publication year.
Effect of a Robot Pet Companion on the Mood of Older Adults Receiving Family Caregiver Support: Pilot RCT
The American Journal of Geriatric Psychiatry20262 influential citations<h4>Background and objectives</h4>Use of companion robot pets to reduce social isolation and loneliness in older people is well-established. Outcomes associated with the pets are promising in residential care settings but less clear in…
Randomised controlled effectiveness study (RCT) of isometric exercise (IE) in adults with stage 1 and 2 hypertension – ISOFITTER study
NIHR Open Research2026n=5421 influential citationsBackground High blood pressure (BP) affects more than one in four adults in England and only one in three patients are being treated effectively. Treatment of high BP includes changes to lifestyle such as more physical activity and/or…
Proteomic effects of short-term liraglutide vs. placebo in a blinded crossover RCT: Implications for efficacy, safety, and comparison with semaglutide
Metabolism20261 influential citations<h4>Background</h4>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert cardiometabolic benefits beyond weight loss, yet their systemic proteomic mechanisms remain incompletely defined. We profiled short-term liraglutide-induced…
Primary posterior tracheopexy in esophageal atresia with tracheomalacia: From innovation to multicenter RCT
Journal of Pediatric Surgery20261 influential citations<h4>Background</h4>Tracheomalacia (TM) is a common comorbidity in children with esophageal atresia (EA), reported in up to 87 % of patients. Around 30 % of EA patients develop severe TM associated with recurrent respiratory morbidity. In…
My Diabetes & Me: study protocol for a randomised controlled trial to test the clinical and cost-effectiveness of a diabetes self-management education programme for adults with intellectual disabilities.
NIHR Open Res2025n=4501 influential citations<h4>Background</h4>International guidelines recommend structured diabetes education to empower individuals with type 2 diabetes (T2D). While DESMOND is an effective programme for T2D management, it is often inaccessible to people with…
Outpatient regimens to reduce COVID-19 hospitalizations: a systematic review and meta-analysis of randomized controlled trials
medRxiv2022Background During pandemics, early outpatient treatments reduce the health system burden. Randomized controlled trials (RCTs) in COVID-19 outpatients have tested therapeutic agents, but no RCT or systematic review has been conducted…
Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences: The THRIVE Study Protocol for a Randomized Controlled Trial.
Research square2026n=210EAdverse Childhood experiences (ACEs) disproportionately affect minoritized and low-income youth. Those with four or more ACEs are particularly vulnerable to chronic, unpredictable stress, which shapes their stress perception and response.…
Testosterone Therapy and Associated Rates of Tendon Tear and Surgical Repair: A Retrospective Analysis.
Orthopaedic journal of sports medicine2026n=14,474ETestosterone replacement therapy (TRT) use is increasing in both men and women with demonstrated benefits for muscle strength, sexual function, and well-being. However, previous studies have linked exogenous testosterone to elevated rates…
Social Media Support Groups for Youth Nicotine Vaping Cessation: An RCT
American Journal of Preventive Medicine2026<h4>Introduction</h4>E-cigarettes are the most frequently used tobacco product among adolescents and young adults. Over 40% of adolescents who used E-cigarettes tried quitting in 2023, but few programs support them, particularly on social…
Guiding generation Z to healthier beverages: Exploratory comparative RCT findings on four front-of-package labels in a policy-gap context
Appetite2026Against the backdrop of China's plan to promote front-of-package (FoP) nutrition labelling under the Healthy China Initiative (2019-2030), evidence on the behavioral effects of different FoP formats among Chinese consumers remains limited,…
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Biohacking studies: how to research evidence-based in 2026?
Go straight to the scientific literature (over 36 million publications, NIH-funded databases, free). Filter for meta-analysis or RCT, sample size >100, published in the last 5 years. For fresher preprints, open preprint servers. For citation impact, citation-ratio metrics (RCR score). Influencer sources like Bulletproof or Goop aren't research — they're marketing.
Which supplements actually work? RCT check 2026
Only a handful of supplements show robust effects in randomized trials: creatine monohydrate (3-5 g/day, strength and cognition), omega-3 EPA/DHA (2-4 g/day, triglyceride reduction), magnesium (in deficiency: better sleep quality), vitamin D (when deficient, not prophylactically). Multivitamins, greens powders, and most adaptogens show no relevant effects on hard endpoints in healthy adults.
Which biohacking tips are scientifically proven? Top 6 evidence-backed 2026
Six biohacks have dense meta-analysis evidence: strength training (mortality −20 %), Finnish sauna 4-7×/week (cardiovascular mortality −50 %), sleep consistency (cognitive performance), Mediterranean diet (PREDIMED: −30 % cardiovascular events), zone-2 cardio (mitochondrial capacity), 8-week mindfulness (stress markers, systematic-review-grade). Everything else is weaker or open.
Zinc: Effects & Evidence—what’s proven and what isn’t
Zinc: an evidence-based overview of efficacy, dosage, and risks. What do meta-analyses, RCTs, and studies show? Plain language—with caveats.
Whey vs. Casein: Effects & Evidence — what’s actually supported
An evidence-based overview of whey and casein: what studies truly show (e.g., muscle protein synthesis), what remains unclear, and what you should practically consider.
More topics in Vitamins & Minerals
Magnesium
Magnesium types, sleep, cramps, stress, and dosage.
Creatine Monohydrate
Power, muscle building, cognition, and safety of creatine.
Ashwagandha
Stress, sleep, cortisol, and possible side effects.
Melatonin Optimization
Melatonin needs, dosing (0.3-5 mg), extended-release forms, circadian rhythm, and long-term safety considerations.
Caffeine + L-Theanine
Caffeine, L-Theanine, focus, alertness and tolerance.
NAD+ Precursors
NMN, NR, NAD+, aging biology and evidence landscape.
Omega-3 Fatty Acids
EPA, DHA, ALA: daily needs, sources (fish, algae), Omega-3 index as biomarker, and cardiovascular RCT data.
Vitamin Optimization
Vitamin optimization strategies: needs assessment, bioavailability, synergies, and safety upper limits for the most relevant micronutrients.
Melatonin Signaling
Melatonin as a multi-system hormone: antioxidant, immunomodulatory, mitochondrial, and neuroprotective effects beyond sleep.
Animal vs Human Studies
Mouse ≠ human — translatability from resveratrol to rapamycin is shaky.
Bias
Sponsorship, selection bias, confirmation bias, industry funding.
Cardiovascular System
Blood pressure, heart rate, endothelium, cholesterol, cardiovascular risk factors.
Contraindications
When something must NOT be taken: pregnancy, pre-existing conditions.
Coenzyme Q10 (CoQ10 / Ubiquinol)
Mitochondria, statins, energy, and cardiovascular outcomes.
Correlation vs Causation
The classic misinterpretation of popular health studies.
Curcumin
Inflammation, bioavailability (piperine), turmeric extracts, and clinical outcomes.
Digestive System
Stomach acid, enzymes, absorption, the gut-brain axis, the microbiome.
Effect Size
p-value vs. practical relevance, Cohen's d, confidence intervals.
Ferritin & Iron
Ferritin, transferrin saturation, iron deficiency vs. iron overload.
Glutathione
Master antioxidant, liposomal vs. NAC forms and detoxification.
Related topics from other worlds
EMF
A contested topic — the evidence, the precautionary principle, the practical side.
Hydration
Water needs, electrolytes, over-/underhydration, urine as an indicator.
Light Therapy
10,000-lux daylight lamp — SAD, jet lag, shift work.
Micronutrients
Vitamins, minerals, trace elements — meeting your needs through diet.
Noise
Chronic noise — stress, sleep quality, hearing loss.
Relationships
The strongest longevity predictor — quality over quantity.