GlutathioneEvidence & Dosage
Master antioxidant, liposomal vs. NAC forms and detoxification.
Evidence at a glance
- Total studies
- 705
- With abstract
- 50
- Meta / Systematic / RCT
- 126
- Highly cited
- 50
- Publication years
- 2000–2026
Glutathione in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on Glutathione
Ranked by influential-citation count and publication year.
Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review.
J Nanobiotechnology2024Systematic Review171 influential citationsSpatiotemporally controlled cargo release is a key advantage of nanocarriers in anti-tumor therapy. Various external or internal stimuli-responsive nanomedicines have been reported for their ability to increase drug levels at the diseased…
Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis.
J Clin Periodontol2019n=2,972Meta-Analysis119 influential citationsAim Oxidative stress ( OS ) biomarkers have been detected in saliva and gingival crevicular fluid ( GCF ) during chronic periodontitis ( CP ) progression; however, the relationship between OS biomarkers and CP progression remains elusive.…
Finding: Chronic periodontitis was associated with significant increases in salivary malondialdehyde, nitric oxide, total oxidant status, and 8-hydroxy-deoxyguanosine levels.
Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis.
Neurobiol Dis2013Meta-Analysis102 influential citationsAbnormal oxidative stress is an established feature of Alzheimer's disease, but clinical trials aiming to reduce oxidative stress have not yet proven an effective therapy for dementia patients. The purpose of this review is to…
Finding: In this meta-analysis, markers of lipid peroxidation were elevated in blood in both Alzheimer's disease and mild cognitive impairment.
Oxidative stress marker aberrations in children with autism spectrum disorder: a systematic review and meta-analysis of 87 studies (N = 9109).
Transl Psychiatry2021n=910Meta-Analysis102 influential citationsThere is increasing awareness that oxidative stress may be implicated in the pathophysiology of autism spectrum disorder (ASD). Here we aimed to investigate blood oxidative stress marker profile in ASD children by a meta-analysis. Two…
Finding: In this meta-analysis of 87 studies, children with ASD had higher blood concentrations of GSSG, malondialdehyde, homocysteine, S-adenosylhomocysteine, nitric oxide, and copper than healthy control children.
Sleep deprivation and oxidative stress in animal models: a systematic review.
Oxid Med Cell Longev2015n=44Meta-Analysis98 influential citationsBecause the function and mechanisms of sleep are partially clear, here we applied a meta-analysis to address the issue whether sleep function includes antioxidative properties in mice and rats. Given the expansion of the knowledge in the…
Oxidative stress-related biomarkers in autism: systematic review and meta-analyses.
Free Radic Biol Med2012Meta-Analysis95 influential citationsAutism spectrum disorders (ASDs) are rarely diagnosed in children younger than 2 years, because diagnosis is based entirely on behavioral tests. Oxidative damage may play a central role in this pathogenesis, together with the…
Oxidative stress and frailty: A systematic review and synthesis of the best evidence.
Maturitas2017n=6,349Systematic Review93 influential citations<h4>Objective</h4>Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to…
Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials.
Pharmacol Res2019n=2,875Meta-Analysis87 influential citationsOmega-3 fatty acids (omega-3 FAs) supplementation effects on oxidants and antioxidants are always controversial. Oxidative stress (OS) is one of the major mechanisms that contribute to the pathogenesis of several chronic diseases. The…
Biomarker responses in fish exposed to polycyclic aromatic hydrocarbons (PAHs): Systematic review and meta-analysis.
Environ Pollut2018Meta-Analysis80 influential citationsBiomarkers of antioxidant and biotransformation systems are commonly used to assess polycyclic aromatic hydrocarbons (PAHs) pollution in fish. Despite their extensive application of biomarkers, contradictory results are vastly reported in…
Finding: PAHs exposure significantly affected biomarker responses in fish.
Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis.
Alzheimers Res Ther2022Meta-Analysis76 influential citationsBackground Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD) and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though…
Finding: Alzheimer’s disease had lower intracellular and extracellular blood glutathione overall compared with healthy controls.
Frequently asked
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Are there safety considerations for Glutathione?
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