NAD+ PrecursorsEvidence & Dosage
NMN, NR, NAD+, aging biology and evidence landscape.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 50
- Meta / Systematic / RCT
- 32
- Highly cited
- 44
- Publication years
- 1999–2026
NAD+ Precursors in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on NAD+ Precursors
Ranked by influential-citation count and publication year.
NAD⁺ in aging, metabolism, and neurodegeneration.
Science2015Review200 influential citationsNicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a…
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.
Geroscience2023n=80rct145 influential citationsIn animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. However, it is unclear if these effects…
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.
Nat Med2024n=1,162Meta-Analysis142 influential citationsDespite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD risk remains even for individuals receiving all guideline-recommended interventions. Niacin is an essential micronutrient fortified in food…
Regulation of and challenges in targeting NAD(+) metabolism.
Nat Rev Mol Cell Biol2024Review136 influential citationsNicotinamide adenine dinucleotide, in its oxidized (NAD<sup>+</sup>) and reduced (NADH) forms, is a reduction-oxidation (redox) co-factor and substrate for signalling enzymes that have essential roles in metabolism. The recognition that…
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.
Adv Nutr2023n=10review95 influential citationsThe importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well recognized. As the NAD+ concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD+…
Roles of NAD(+) in Health and Aging.
Cold Spring Harb Perspect Med2024Review64 influential citationsNAD<sup>+</sup>, the essential metabolite involved in multiple reactions such as the regulation of cellular metabolism, energy production, DNA repair, mitophagy and autophagy, inflammation, and neuronal function, has been the subject of…
Finding: NAD+ levels decline with aging and in some age-related diseases.
Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review and network meta-analysis of randomized controlled trials.
Pharmacol Res2023n=142Meta-Analysis59 influential citationsMedical nutrition treatment can manage diabetes and slow or prevent its complications. The comparative effects of micronutrient supplements, however, have not yet been well established. We aimed at evaluating the comparative effects of…
Finding: In this systematic review and network meta-analysis, chromium supplements ranked best for reducing fasting blood glucose levels and homeostasis model assessment of insulin resistance.
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta-analysis.
Front Immunol2022n=689Meta-Analysis57 influential citationsBackground Tryptophan (TRP) is an essential amino acid that must be provided in the diet. The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide adenosine dinucleotide (NAD + ), and metabolites of this pathway…
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment.
GeroScience2024B57 influential citationsNicotinamide riboside (NR) increases blood levels of NAD+, a cofactor central to energy metabolism, and improves brain function in some rodent models of neurodegeneration. We conducted a placebo-controlled randomized pilot study with the…
Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial.
Nature communications2024n=90B53 influential citationsPeople with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial…
Frequently asked
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Related articles
NAD+ Precursors - What are the Most Effective Ones?
The most effective NAD+ precursors, according to studies, are Nicotinamide Riboside (NR), Nicotinic Acid, and NMN. These substances can help increase the NAD+ levels in your body.
NAD+ Precursors: Effects, Safety, and the State of the Evidence
Evidence-based overview of NAD+ precursors such as NMN and NR: what studies have shown, where data are missing, and what risks and limitations are known?
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