Cardiovascular SystemEvidence & Dosage
Blood pressure, heart rate, endothelium, cholesterol, cardiovascular risk factors.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 36
- Meta / Systematic / RCT
- 4
- Highly cited
- 4
- Publication years
- 1938–2026
Cardiovascular System in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on Cardiovascular System
Ranked by influential-citation count and publication year.
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.
JAMA2003n=6,391200 influential citations<h4>Context</h4>Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in…
Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.
J Pain Symptom Manage2010n=177RCT147 influential citationsThis study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced cancer. In…
Efficacy and safety evaluation of intensive statin therapy in older patients with coronary heart disease: a systematic review and meta-analysis.
Eur J Clin Pharmacol2013n=11,132Meta-Analysis15 influential citations<h4>Purpose</h4>To reveal and evaluate the efficacy and safety of intensive statin therapy in older patients (age ≥ 65 years) with coronary heart disease (CHD).<h4>Methods</h4>Electronic databases were searched for randomized controlled…
Projected reduction in major adverse cardiovascular events among high-risk U.S. adults with type 2 diabetes eligible for oral semaglutide: a SOUL trial-based analysis using NHANES (1988-2018) cycles.
Cardiovascular diabetology. Endocrinology reports2026EBackground Oral semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been shown to reduce major adverse cardiovascular events (MACE) in high-risk individuals with type 2 diabetes in the SOUL trial. Its potential…
Cardiovascular outcomes of glucagon-like peptide-1 receptor agonists: A systematic review.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2026ETo identify and evaluate cardiovascular outcome trials for glucagon-like peptide-1 receptor agonists (GLP1RAs) in various patient populations, including those with or without type 2 diabetes (T2D). A systematic search of MEDLINE identified…
Effects of tirzepatide, a dual GIP and GLP-1 receptor agonist, on blood pressure, cardiac function, and sympathetic nervous system in stroke-prone spontaneously hypertensive rats.
2026n=9Tirzepatide, a dual agonist for glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has shown robust efficacy in treating diabetes and obesity, and in obese patients with heart failure with…
Feasibility of a Home-based Transcutaneous Spinal Stimulation Program on Autonomic-Cardiovascular Safety After Incomplete Tetraplegia.
Topics in spinal cord injury rehabilitation2026n=4BWe examined the safety and feasibility of delivering a home-based transcutaneous spinal stimulation (TSS) program in persons with incomplete tetraplegia. We also explored the cardiovascular-autonomic safety during the program. Males with…
Two variations of Commando-Nicks approach for calcified aortic and mitral valve disease.
Multimedia manual of cardiothoracic surgery : MMCTS2026Surgery for radiation-associated valve disease is technically demanding due to challenging exposure, extensive calcification, and risk of paravalvular leak or atrioventricular groove disruption. An oblique aortotomy revealed heavy…
Lateral Circumflex Femoral Artery Pseudoaneurysm Post-Hip Arthroscopy and Periacetabular Osteotomy in Ehlers-Danlos Syndrome: A Case Report.
JBJS case connector2026Case: An 18-year-old woman with Ehlers–Danlos syndrome developed subacute thigh pain on postoperative day 21 following elective hip arthroscopy and a periacetabular osteotomy. Doppler ultrasound revealed a pulsatile “yin–yang” lesion in…
Neural mechanisms underlying blood pressure dynamics and cardiovascular control.
Am J Physiol Heart Circ Physiol2026ReviewBlood pressure regulation involves bidirectional brain-heart interactions mediated by both neurochemical signals and mechanosensitive pathways that include recently identified piezo receptors. We review current findings on the dynamic…
Frequently asked
What dosage was studied?
Are there safety considerations for Cardiovascular System?
Related articles
Omega-3 Fatty Acids - What Are the Scientific Evidence?
Omega-3 fatty acids have a positive effect on the cardiovascular system. Studies show a reduction in heart attacks and strokes. The recommended daily dose is 250-500 mg EPA+DHA.
Magnesium - What are the Scientific Evidence?
Magnesium is an essential mineral that is necessary for over 300 bodily functions. It ensures normal muscle and nerve function, supports blood pressure, and helps with bone health.
More topics in Vitamins & Minerals
Magnesium
Magnesium types, sleep, cramps, stress, and dosage.
Creatine Monohydrate
Power, muscle building, cognition, and safety of creatine.
Ashwagandha
Stress, sleep, cortisol, and possible side effects.
Melatonin Optimization
Melatonin needs, dosing (0.3-5 mg), extended-release forms, circadian rhythm, and long-term safety considerations.
Caffeine + L-Theanine
Caffeine, L-Theanine, focus, alertness and tolerance.
NAD+ Precursors
NMN, NR, NAD+, aging biology and evidence landscape.
Omega-3 Fatty Acids
EPA, DHA, ALA: daily needs, sources (fish, algae), Omega-3 index as biomarker, and cardiovascular RCT data.
Vitamin Optimization
Vitamin optimization strategies: needs assessment, bioavailability, synergies, and safety upper limits for the most relevant micronutrients.
Melatonin Signaling
Melatonin as a multi-system hormone: antioxidant, immunomodulatory, mitochondrial, and neuroprotective effects beyond sleep.
Animal vs Human Studies
Mouse ≠ human — translatability from resveratrol to rapamycin is shaky.
Bias
Sponsorship, selection bias, confirmation bias, industry funding.
Contraindications
When something must NOT be taken: pregnancy, pre-existing conditions.
Coenzyme Q10 (CoQ10 / Ubiquinol)
Mitochondria, statins, energy, and cardiovascular outcomes.
Correlation vs Causation
The classic misinterpretation of popular health studies.
Curcumin
Inflammation, bioavailability (piperine), turmeric extracts, and clinical outcomes.
Digestive System
Stomach acid, enzymes, absorption, the gut-brain axis, the microbiome.
Effect Size
p-value vs. practical relevance, Cohen's d, confidence intervals.
Ferritin & Iron
Ferritin, transferrin saturation, iron deficiency vs. iron overload.
Glutathione
Master antioxidant, liposomal vs. NAC forms and detoxification.
Immune System
Innate vs. adaptive immunity, inflammation, autoimmunity.
Related topics from other worlds
Glycine
Methylation, collagen synthesis, lifespan signals in animal models.
Mitochondrial Health
Biogenesis, mitophagy, MitoQ and PQQ strategies.
Sarcopenia
Age-related muscle loss — strength training + protein are the best prevention.
Time-Restricted Eating
8/16 or similar — autophagic and metabolic effects.
Anxiety
Acute anxiety vs. an anxiety disorder, the neurobiology, interventions.
Cold Exposure (Mood)
Norepinephrine, depression, and mood effects of cold.